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2022 年度 実績報告書

肝臓に転移した膵管腺癌の増悪化を再現する病態生理学的な培養組織モデル

研究課題

研究課題/領域番号 22K18182
研究機関東京大学

研究代表者

DANOY MATHIEU  東京大学, 大学院工学系研究科(工学部), 助教 (90882621)

研究期間 (年度) 2022-04-01 – 2023-03-31
キーワードTumor / Pancreas / Liver / hiPSCs / Stroma / Fibroblasts / Macrophages / Cancer
研究実績の概要

The differentiation of hiPSCs-derived tumor models has been achieved with several cell lines. Depending on the cancer cell line used for the induction, the models were found to express markers typical of cancer stem cells, tumor-associated macrophages, and cancer-associated fibroblasts. The function has also been tested for those cell types in terms of proteins such as Ki67. The different models have been sorted to investigate the percentage in each cell type of each model. The project has been prematurely ended due to a change of employment of the principal investigator.

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公開日: 2023-12-25  

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