| 研究実績の概要 |
In this study, we have developed a self-assembled iron oxide nanoparticle-based contrast agent that holds immense potential for high-resolution imaging of the cerebrovasculature. The branched polyethylene glycols, with a molecular weight of approximately 10 kDa, are conjugated with iron oxide nanoparticles and fluorescein. The self-assembled fiber structure, formed by electrostatic interaction, is concentration-dependent. At 25 mg/ml, self-assembly fibers measuring 120 nm in length and 50 nm in width are detected. Most importantly, when administered intravenously in a rat model, our self-assembly contrast revealed a significantly enhanced cerebral microvascular network, a finding that could revolutionize conventional MRI imaging. The research findings, which have been presented at several prestigious domestic conferences, have also been published in a renowned international journal.
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