| 研究実績の概要 |
Our data showed that CD206KO mice are insulin-sensitive with reduced expression of the inflammatory genes in visceral white adipose tissue. This data further suggests that CD206 M2 macrophages are actively involved in regulating glucose metabolism. However, how these M2 anti-inflammatory macrophages phenotypically switch to pro-inflammatory M1 type under a high-fat diet is under debate. My focus is to investigate the underlying molecular mechanism that regulates these shifting/switching of macrophages, resulting in insulin resistance under high-fat diet-fed conditions. Furthermore, I am generating CD206 flox mice to knock down the CD206 M2 signaling conditionally. This will further help me to explore the underlying regulatory mechanism for the treatment of obesity and type 2 diabetes.
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