| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
After synthesizing the final monomer ligand with flexible hydrophobic tail and polar aza-crown ether unit, I will optimize (choice of metal ions, solvent, critical concentration, temperature, pH) the formation of mechanically robust 2D bilayer-nanotube. I have developed a new strategy to functionalize the PCH with different reactive groups (-NH2, -OH, -maleimide) for further studies. Although the nanofibers are quite large enough to see with optical microscopy the actual arrangement of the PHC in the fiber is not clear, whether it is rod like or tube-like structures. We are expecting to solve this problem by characterization through electron microscopy, AFM and 2D WAXD. To check our hypothesis and further biological studies, I must attach a water-soluble hydrophilic dye molecule with PHC.
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| 今後の研究の推進方策 |
After synthesizing the final terpyridine/pyridine-based monomer ligand with flexible hydrophobic tail and polar aza-crown ether unit, I will characterize through nuclear magnetic resonance and mass spectroscopy. Optimization (choice of metal ions, solvent, critical concentration, temperature, pH) of the formation of mechanically robust 2D bilayer-nanotube will be done. Finally, I would like to check the mechanical properties of such fibers. Also, the charge distribution of PHC suggest that it can break the water cluster barrier of cell membrane. We expect that perfluorinated-crownether can solve the problem of blood brain barrier by acting as a small drug carrier. I must attach a water-soluble hydrophilic dye molecule with PHC for further studies.
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