| 研究課題/領域番号 |
21F21037
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| 配分区分 | 補助金 |
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| 研究機関 | 国立研究開発法人理化学研究所 |
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研究代表者 |
相田 卓三 国立研究開発法人理化学研究所, 創発物性科学研究センター, グループディレクター (00167769)
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| 研究分担者 |
GOSWAMI ABIR 国立研究開発法人理化学研究所, 創発物性科学研究センター, 外国人特別研究員
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| 研究期間 (年度) |
2021-11-18 – 2024-03-31
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| キーワード | Perfluorinated Crown / Supramolecular Adhesive / Water Cluster / Membrane Transporter |
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| 研究実績の概要 |
Our novel synthetic strategy for functionalizing perfluoro crown ethers has potential applications in various fields. Strategically designed crown ether derivatives form strong supramolecular polymers in the molten state with high adhesive strength and toughness, attributed to dynamic hydrogen bonding and Fluorine-Fluorine interactions. This material shows excellent underwater and PTFE sheet adhesion, making it a potential replacement for conventional adhesive polymers. Additionally, crown ether derivatives exhibit strong interactions with water clusters, allowing them to penetrate cell membranes quickly. Whereas the corresponding nonfluorinated analog failed to penetrate the membrane bilayer even after prolonged incubation, making them suitable for medicinal chemistry and drug delivery.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
1: 当初の計画以上に進展している
理由
We developed an efficient method for functionalizing perfluoro crown ethers in a very short time. Initially, we struggled to functionalize the commercially available, poorly soluble Perfluoro-15-crown-5 ether, which was expected due to the strong and inert C-F bond in perfluoro carbons. However, we were pleasantly surprised to obtain a high yield of perfluorocrown ethers, allowing us to explore their potential applications in various fields of chemistry. Most importantly, we discovered that these compounds exhibit outstanding and unexpected properties, including the ability to break the hydration layer and penetrate cell membranes directly, as well as demonstrating mechanically tough supramolecular adhesion through dynamic F-F interactions.
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| 今後の研究の推進方策 |
Perfluoro molecules are extensively used in various fields of chemistry. In near future, we would like to explore the effects of fluorine in supramolecular polymerization and medicinal chemistry. We expect to use this perfluorinated crown ether carrier to tackle the most difficult challenges of drug delivery to the brain and 19F MRI imaging.
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