| 研究実績の概要 |
Studying biological processes with the help of biomaterials that mimic both mechanical and biochemical cues is an effective way to understand cellular responses, especially those related to the cytoskeletal system. To achieve this goal, we have used cRGD concentration as a biochemical cue to investigate the relationship between MTs and cellular mechanics and morphology. Our study has shown that the contribution of MTs to cellular stiffness and morphology is dependent on the underlying cRGD densities. (These results have been submitted, and the research article is currently being revised.)
In collaborative research, we employed photoactivatable surfaces to explore the influence of confinement, among other environmental stimuli like cellular phenotypes and cytoskeletal system perturbations, on the stress inside living cells using atomic force microscopy. Our results indicate that changes in intracellular prestress occurs in accordance with the environmental stimuli. This study was published STAM 2023 and selected as news research highlight in several websites.
Additionally, the photoactivatable surfaces have been utilized to show the effect of alteration of ECM compositions on the collective cell migration and leader cell formation, we showed a new correlation between leader cells in collective migration and the biochemical signals that arise from underlying extracellular matrix proteins (These results have been submitted, and the research article is currently being revised.; preliminary results were presented at two conferences)
|
