研究課題
In this study, we focused on the role of specific chemokine interaction in manifesting antigen-specific immune cell migration from nasal mucosa to genital mucosa which is necessary to achieve effective immune responses in genital tract against sexually transmitted infection. The current data showed that nasal immunization with HSV-2 TK- could induce the upregulation of chemokine receptor expression in CD4+ T cells in the antigen priming sites (e.g., CLNs) and vagina tissue. Expressions of ligands of the receptor expressions were all upregulated in vaginal tissue in stromal cells of vaginal tissue after nasal immunization. Furthermore, loss of the receptor, also impairs the migration of nasally primed antigen-specific effector cells from nasal mucosa to the vagina. These results indicate that the novel chemokine interaction is required for the migration and retention of nasally-primed Ag-specific tissue memory effector cells in vagina and further protection of the female reproductive tract against HSV-2 virus. The results generated through this study provide a means to effectively induce and modulate antigen-specific immune responses at the female genital mucosa through the novel chemokine pathway and contribute to the design of nasal vaccines for sexually transmitted diseases (e.g., HSV-2).
27年度が最終年度であるため、記入しない。
すべて 2017 2016
すべて 雑誌論文 (15件) (うち国際共著 15件、 査読あり 15件、 謝辞記載あり 13件、 オープンアクセス 4件) 学会発表 (15件) (うち国際学会 13件、 招待講演 14件) 図書 (7件)
Mucosal Immunology
巻: - ページ: -
10.1038/mi.2016.103.(in printing)
PLoS One
巻: 12 ページ: -
10.1371/journal.pone.0172795. eCollection 2017
Science Reports
in printing
Journal of Controlled Release
submitted
Nature Communications
巻: 8 ページ: 14509
10.1038/ncomms14509
International Immunology
10.1038/mi.2016.137. in printing
doi: 10.1371/journal.pone.0172509
Immunology & Cell Biology
巻: 95 ページ: 117-8
10.1038/icb.2016.106
10.1093/intimm/dxx019
Annual Review of Immunology
巻: - ページ: 51116-52424
10.1146/annurev-immunol-051116-052424
Regulatory Toxicology and Pharmacology
巻: 76 ページ: 128-136
10.1016/j.yrtph.2016.01.023.
Journal of Hypertension
巻: 1 ページ: 42
Nature Immunology
巻: 17 ページ: 1244-1251
10.1038/ni.3587
BMB Reports
巻: 49 ページ: 263-9
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