高速エネルギー弁別Ｘ線ＣＴシステムと分子レベルイメージング

2013 年度 研究成果報告書

• 研究課題/領域番号: 23591791
• 研究種目: 基盤研究(C)
• 配分区分: 基金
• 応募区分: 一般
• 研究分野: 放射線科学
• 研究機関: 岩手医科大学
• 研究代表者: 佐藤 英一 岩手医科大学, 公私立大学の部局等, 教授 (90154038)
• 連携研究者: 小田 泰行 岩手医科大学, 教養教育センター, 助教 (50583671) ; 寒河江 康朗 岩手医科大学, 教養教育センター, 助教 (30235197)
• 研究期間 (年度): 2011 – 2013
• キーワード: Ｘ線CT / エネルギー弁別CT / 高速CdTe検出器 / LSO-MPPC検出器 / YAP(Ce)-MPPC検出器 / ヨウ素KエッジCT / ガドリニウムKエッジCT / エネルギーサブトラクション

研究概要

スキャン速度25 mm/sのsub-Mcps CdTeリニアスキャナー，ターンテーブル，Ｘ線装置などを組み合わせて，高速エネルギー弁別Ｘ線CT（ED-CT）システムを構築した。このED-CTにより，ガドリニウムやヨウ素の造影剤を用いたKエッジ撮影を試み，血管や癌などが高コントラストで撮影された。また，CdTe検出器とｘ-ｙステージを組み合わせて，透過式Ｘ線カメラ，反射式蛍光Ｘ線カメラ，そして後方散乱カメラも構築した。さらに，Mcps領域での撮影を行うために，LSO-MPPCやYAP(Ce)-MPPC検出器も開発し，これらを用いて高速ED-CTシステムを構築し，高速Kエッジ撮影に成功した。

研究成果

• [雑誌論文] Zero-dark-counting high-speed X-ray photon detection using a cerium-doped yttrium aluminum perovskite crystal and a small photomultiplier tube and its application to gadolinium imaging (2014)
  • 著者名/発表者名: S. Yamaguchi, E. Sato, Y. Oda, R. Nakamura, H. Oikawa, T. Yabuushi, H. Ariga, S. Ehara
  • 雑誌名: Jpn. J. Appl. Phys 巻: 53 ページ: 040304-1-4
  • 査読あり
• [雑誌論文] Zero-dark-counting X-ray photon detection using a YAP(Ce)-MPPC detector and its application to computed tomography using gadolinium contrast media (2014)
  • 著者名/発表者名: S. Kami, E. Sato, H. Kogita, W. Numahata, T. Hamaya, S. Nihei, Y. Arakawa, Y. Oda, H. Kodama, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, M. Watanabe, S. Kusachi, S. Sato, A. Ogawa
  • 雑誌名: Rad. Phys. Chem 巻: 100 ページ: 1-7
  • 査読あり
• [雑誌論文] Investigation of X-ray photon-counting using ceramic-substrate silicon diode and its application to gadolinium imaging (2014)
  • 著者名/発表者名: Y. Arakawa, E. Sato, H. Kogita, T. Hamaya, S. Nihei, W. Numahata, S. Kami, Y. Oda, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, M. Watanabe, S. Kusachi, S. Sato, A. Ogawa
  • 雑誌名: Jpn. J. Appl. Phys 巻: 53 ページ: 072201-1-5
  • 査読あり
• [雑誌論文] Image-quality improvement in pileup-less cadmium-telluride X-ray computed tomography using a frequency-voltage converter and its application to iodine imaging (2014)
  • 著者名/発表者名: A. Shimamura, E. Sato, S. Shikanai, K. Kitakami, I. Nakaya, W. Nishikawa, Y. Sato, S. Yamaguchi, Y. Oda, O. Hagiwara, H. Matsukiyo, T. Enomoto, M. Watanabe, S. Kusachi, S. Ehara
  • 雑誌名: Med. Imag. Inform. Sci 巻: 31(in press)
  • 査読あり
• [雑誌論文] Low-dose-rate computed tomography system utilizing 25 mm/s-scan silicon X-ray diode and its application to iodine K-edge imaging using filtered bremsstrahlung photons (2013)
  • 著者名/発表者名: R. Matsushita, E. Sato, Y. Yanbe, H. Chiba, T. Maeda, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, M. Watanabe, S. Kusachi, S. Sato, A. Ogawa, J. Onagawa
  • 雑誌名: Jpn. J. Appl. Phys 巻: 52 ページ: 032202-1-5
  • 査読あり
• [雑誌論文] X-ray photon counting using 100 MHz ready-made silicon P-intrinsic-N X-ray diode and its application to energy-dispersive computed tomography (2013)
  • 著者名/発表者名: H. Kodama, M. Watanabe, E. Sato, Y. Oda, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, S. Kusachi, S. Sato, A. Ogawa
  • 雑誌名: Jpn. J. Appl. Phys 巻: 52 ページ: 072202-1-6
  • 査読あり
• [雑誌論文] High-sensitivity high-speed X-ray fluorescence scanning cadmium telluride detector for deep-portion cancer diagnosis utilizing tungsten-Kα-excited gadolinium mapping (2013)
  • 著者名/発表者名: Y. Yanbe, E. Sato, H. Chiba, T. Maeda, R. Matsushita, Y. Oda, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, M. Watanabe, S. Kusachi, S. Sato, A. Ogawa
  • 雑誌名: Jpn. J. Appl. Phys 巻: 52 ページ: 092201-1-4
  • 査読あり
• [雑誌論文] Investigation of dark-count-less Lu_2(SiO_4)O-multipixel-photon detector and its application to photon counting X-ray computed tomography using iodine media (2013)
  • 著者名/発表者名: E. Sato, Y. Oda, H. Kodama, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, M. Watanabe, S. Kusachi, S. Sato, A. Ogawa
  • 雑誌名: Jpn. J. Appl. Phys 巻: 52 ページ: 092401-1-6
  • 査読あり
• [雑誌論文] X-ray detection using a ceramic-substrate silicon X-ray diode and its application to computed tomography using gadolinium media (2013)
  • 著者名/発表者名: Y. Oda, E. Sato, M. Sagae, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, M.Watanabe, S. Kusachi, S. Sato, A. Ogawa
  • 雑誌名: Med. Imag. Inform. Sci 巻: 29 ページ: 70-75
  • 査読あり
• [雑誌論文] 15 Mcps photon-counting X-ray computed tomography system using a ZnO-MPPC detector and its application to gadolinium imaging (2012)
  • 著者名/発表者名: E. Sato, S. Sugimura, H. Endo, Y. Oda, A. Abudurexiti, O. Hagiwara, A. Osawa, H. Matsukiyo, T. Enomoto, M. Watanabe, S. Kusachi, S. Sato, A. Ogawa, J. Onagawa
  • 雑誌名: Appl. Rad. Isot 巻: 70 ページ: 336–340
  • 査読あり
• [雑誌論文] Demonstration of enhanced iodine K-edge imaging using an energy-dispersive X-ray computed tomography system with a 25 mm/s-scan linear cadmium telluride detector and a single comparator (2012)
  • 著者名/発表者名: E. Sato, Y. Oda, A. Abudurexiti, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, M. Watanabe, S. Kusachi, S. Sato, A. Ogawa, J. Onagawa
  • 雑誌名: Appl. Rad. Isot 巻: 70 ページ: 831–836
  • 査読あり
• [雑誌論文] Investigation of energy-dispersive X-ray computed tomography system with CdTe scan detector and comparing-differentiator and its application to gadolinium K-edge imaging (2012)
  • 著者名/発表者名: H. Chiba, Y. Sato, E. Sato, T. Maeda, R. Matsushita, Y. Yanbe, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, M. Watanabe, S. Kusachi, S. Sato, A. Ogawa, J. Onagawa
  • 雑誌名: Jpn. J. Appl. Phys 巻: 51 ページ: 102402-1-5
  • 査読あり
• [雑誌論文] Investigation of a high-count-rate energy-disiersive X-ray CT system using a CdTe detector and a high-speed comparator and its application to iodine K-edge imaging (2012)
  • 著者名/発表者名: Y. Sato, E. Sato, S. Ehara, Y. Oda, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, M. Watanabe, S. Kusachi, S. Sato, A. Ogawa, J. Onagawa
  • 雑誌名: Med. Imag. Inform. Sci 巻: 29 ページ: 56-61
  • 査読あり
• [雑誌論文] 100μA-100 kV photon-counting X-ray computed tomography system using an LSO-MPPC detector and a high-speed comparator and its application to gadolinium imaging (2012)
  • 著者名/発表者名: T. Maeda, E. Sato, R. Matsushita, Y. Yanbe, H. Chiba, Y. Oda, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, M. Watanabe, S. Kusachi, S. Sato, A. Ogawa, J. Onagawa
  • 雑誌名: J. Med. Imag. Radiat. Sci 巻: 43 ページ: 149-154
  • 査読あり
• [雑誌論文] 250 kcps photon-counting X-ray CT system using a YAP(Ce) detector and a high-speed inverse comparator and its application to iodine imaging (2012)
  • 著者名/発表者名: Y. Sato, E. Sato, S. Ehara, Y. Oda, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, M. Watanabe, S. Kusachi, S. Sato, A. Ogawa, J. Onagawa
  • 雑誌名: Med. Imag. Inform. Sci 巻: 29 ページ: 51-55
  • 査読あり
• [雑誌論文] Demonstration of 10 keV-width K-edge Imaging Using an Energy-Discrimination X-ray Computed Tomography System Utilizing a Silicon-PIN Detector (2011)
  • 著者名/発表者名: O. Hagiwara, M. Watanabe, E. Sato, H. Matsukiyo, A. Osawa, J. Nagao
  • 雑誌名: Med. Imag. Inform. Sci 巻: 28 ページ: 24-29
  • 査読あり
• [雑誌論文] Conventional X-ray fluorescence camera with a cadmium-telluride detector and its application to cancer diagnosis (2011)
  • 著者名/発表者名: T. Enomoto, E. Sato, P. Abderyim, A. Abudurexiti, O. Hagiwara, H. Matsukiyo, A. Osawa, M. Watanabe, J. Nagao, S. Sato, A. Ogawa, J. Onagawa
  • 雑誌名: Nucl. Instr. Meth. A 巻: 635 ページ: 108–115
  • 査読あり
• [雑誌論文] First demonstration of 10 keV-width energy-discrimination K-edge radiography using a cadmium-telluride X-ray camera with a tungsten-target tube (2011)
  • 著者名/発表者名: M. Watanabe, E. Sato, P. Abderyim, A. Abudurexiti, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, J. Nagao, S. Sato, A. Ogawa, J. Onagawa
  • 雑誌名: Nucl. Instr. Meth. A 巻: 637 ページ: 171–177
  • 査読あり
• [雑誌論文] Monochromatic flash embossed radiography using clean K photons from a spherical-plasma target (2011)
  • 著者名/発表者名: A. Osawa, E. Sato, Y. Oda, A. Abudurexiti, P. Abderyim, O. Hagiwara, H. Matsukiyo, T. Enomoto, M. Watanabe, J. Nagao, S. Sato, A. Ogawa, J. Onagawa
  • 雑誌名: Nucl. Instr. Meth. A 巻: 635 ページ: 131–136
  • 査読あり
• [雑誌論文] Application of an oscillation-type linear cadmium telluride detector to enhanced gadolinium K-edge computed tomography (2011)
  • 著者名/発表者名: H. Matsukiyo, E. Sato, O. Hagiwara, A. Abudurexiti, A. Osawa, T. Enomoto, M. Watanabe, J. Nagao, S. Sato, A. Ogawa, J. Onagawa
  • 雑誌名: Nucl. Instr. Meth. A 巻: 632 ページ: 142–146
  • 査読あり
• [雑誌論文] First demonstration of iodine mapping in nonliving phantoms using an X-ray fluorescence computed tomography system with a cadmium telluride detector and a tungsten-target tube (2011)
  • 著者名/発表者名: E. Sato, Y. Sato, S. Ehara, A. Abudurexiti, O. Hagiwara, H. Matsukiyo, A. Osawa, T. Enomoto, M. Watanabe, J. Nagao, S. Sato, A. Ogawa, J. Onagawa
  • 雑誌名: Nucl. Instr. Meth. A 巻: 638 ページ: 187-191
  • 査読あり
• [雑誌論文] Iodine X-ray fluorescence computed tomography system utilizing a cadmium telluride detector in conjunction with a cerium-target tube (2011)
  • 著者名/発表者名: O. Hagiwara, M. Watanabe, E. Sato, H. Matsukiyo, A. Osawa, T. Enomoto, J. Nagao, S. Sato, A. Ogawa, J. Onagawa
  • 雑誌名: Nucl. Instr. Meth. A 巻: 640 ページ: 170-175
  • 査読あり
• [雑誌論文] Energy-discrimination X-ray computed tomography system utilizing a silicon-PIN detector and its application to 2.0-keV-width K-edge imaging (2011)
  • 著者名/発表者名: O. Hagiwara, M. Watanabe, E. Sato, H. Matsukiyo, A. Osawa, T. Enomoto, J. Nagao, S. Sato, A. Ogawa, J. Onagawa
  • 雑誌名: Nucl. Instr. Meth. A 巻: 638 ページ: 165-170
  • 査読あり
• [雑誌論文] Mcps-range photon-counting X-ray computed tomography system utilizing an oscillating linear-YAP(Ce) photon detector (2011)
  • 著者名/発表者名: Y. Oda, E. Sato, A. Abudurexiti, O. Hagiwara, A. Osawa, H. Matsukiyo, T. Enomoto, M. Watanabe, S. Kusachi, S. Sugimura, H. Endo, S. Sato, A. Ogawa, J. Onagawa
  • 雑誌名: Nucl. Instr. Meth. A 巻: 643 ページ: 69-74
  • 査読あり
• [雑誌論文] 6 Mcps-range photon-counting X-ray computed tomography system using a 25 mm/s-scan linear LSO-MPPC detector and its application to gadolinium imaging (2011)
  • 著者名/発表者名: E. Sato, Y. Oda, A. Abudurexiti, O. Hagiwara, H. Matsukiyo, A. Osawa,T. Enomoto, M. Watanabe, S. Kusachi, S. Sugimura, H. Endo, S. Sato, A. Ogawa, J. Onagawa
  • 雑誌名: Rad. Phys. Chem 巻: 80 ページ: 1327-1332
  • 査読あり
• [産業財産権] ダークカウントレス放射線検出エネル ギー弁別イメージングシステム (2014)
  • 発明者名: 佐藤英一
  • 権利者名: 岩手医科大学
  • 産業財産権種類: 特許
  • 産業財産権番号: 2014-024663
  • 出願年月日: 2014-02-12
  • 外国
• [産業財産権] X線直接変換イメージングシステム (2013)
  • 発明者名: 佐藤英一
  • 権利者名: 岩手医科大学
  • 産業財産権種類: 特許
  • 産業財産権番号: 2013-170500
  • 出願年月日: 2013-08-20
  • 外国