消化管分化の観点に立った胃癌の発症・進展・組織型決定の分子基盤の解明

2012 年度 研究成果報告書

• 研究課題/領域番号: 23790355
• 研究種目: 若手研究(B)
• 配分区分: 基金
• 研究分野: 病態医化学
• 研究機関: 東京大学
• 研究代表者: 山道 信毅 東京大学, 医学部附属病院, 助教 (30463897)
• 研究期間 (年度): 2011 – 2012
• キーワード: 胃癌 / 胃腺腫 / 胃癌組織型 / 腸上皮化生 / エピジェネティクス / 消化管分化 / cathepsin E (CTSE)

研究概要

胃sig/por癌由来細胞株で強く発現し、胃tub1/tub2/muc癌由来株で欠失し易いCTSEを同定した。胃癌手術症例の検討から、CTSEは胃形質、かつ、胃sig癌のマーカーと考えられた。内視鏡切除した腺腫/tub1/tub2症例では、胃マーカー発現は腫瘍部:tub2>tub1>腺腫、周辺部:腺腫>tub1>tub2、腸マーカー発現は腫瘍・周辺部のいずれも腺腫>tub1>tub2であった。一方、胃sig癌症例では癌・周辺部のいずれも胃マーカー発現が高く、腸マーカー発現が低かった。腺腫/tub1/tub2では『胃形質を失い、かつ、腸への分化が不十分な背景粘膜から、分化度の低い腫瘍が発生し』易く、sigでは『背景の胃形質を反映して発癌する』傾向が、示された。

研究成果

• [雑誌論文] Invasion of poorly differentiated adenocarcinoma to the deep muscularis mucosae may be an indicator of lymph node metastasis in Barrett's esophageal cancer. (2013)
  • 著者名/発表者名: Sakaguchi Y, Ono S, Fujishiro M, Yamamichi N, Koike K
  • 雑誌名: Dig Endosc 巻: 25 ページ: 168-172
• [雑誌論文] Cathepsin E is a marker of gastric differentiation and signet-ring cell carcinoma of stomach: a novel suggestion on gastric tumorigenesis. (2013)
  • 著者名/発表者名: Konno-Shimizu M, Yamamichi N, Inada K, Kageyama-Yahara N, Shiogama K, Takahashi Y, Asada-Hirayama I, Yamamichi-Nishina M, Nakayama C, Ono S et al
  • 雑誌名: PLoS One 巻: 8(2) ページ: e56766
• [雑誌論文] Evaluation of a new image-enhanced endoscopic technology using band-limited light for detection of esophageal squamous cell carcinoma. (2013)
  • 著者名/発表者名: Kodashima S, Fujishiro M, Ono S, Niimi K, Mochizuki S, Asada-Hirayama I, Konno-Shimizu M, Matsuda R, Minatsuki C, Nakayama C, Yamamichi N, et al
  • 雑誌名: Dig Endosc
• [雑誌論文] Factors predictive of inaccurate determination of horizontal extent of intestinal-type early gastric cancers during endoscopic submucosal dissection: A retrospective analysis (2013)
  • 著者名/発表者名: Asada-Hirayama I, Kodashima S, Goto O, Yamamichi N, Ono S, Niimi K, Mochizuki S, Konno-Shimizu M, Mikami-Matsuda R, Minatsuki C et al
  • 雑誌名: Dig Endosc
• [雑誌論文] Narrow band imaging with magnification can pick up esophageal squamous cell carcinoma more efficiently than lugol chromoendoscopy in patients after chemoradiotherapy. (2013)
  • 著者名/発表者名: Asada-Hirayama I, Kodashima S, Fujishiro M, Ono S, Niimi K, Mochizuki S, Konno-Shimizu M, Mikami-Matsuda R, Minatsuki C, Nakayama C, Yamamichi N, et al
  • 雑誌名: Diagn Ther Endosc2013 巻: 2013 ページ: 256439
• [雑誌論文] Rebamipide induces dendritic cell recruitment to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-exposed rat gastric mucosa based on IL-1beta upregulation. (2012)
  • 著者名/発表者名: Yamamichi N, Oka M, Inada K, Konno-Shimizu M, Kageyama-Yahara N, Tamai H, Kato J, Fujishiro M, Kodashima S, Niimi K et al
  • 雑誌名: Biochem Biophys Res Commun 巻: 424(1) ページ: 124-129
• [雑誌論文] Lifestyle factors affecting gastroesophageal reflux disease symptoms: a cross-sectional study of healthy 19864 adults using FSSG scores. (2012)
  • 著者名/発表者名: Yamamichi N, Mochizuki S, Asada-Hirayama I, Mikami-Matsuda R, Shimamoto T, Konno-Shimizu M, Takahashi Y, Takeuchi C, Niimi K, Ono S et al
  • 雑誌名: BMC Med 巻: 10 ページ: 45
• [雑誌論文] Development of gastric cancer in nonatrophic stomach with highly active inflammation identified by serum levels of pepsinogen and Helicobacter pylori antibody together with endoscopic rugal hyperplastic gastritis. (2012)
  • 著者名/発表者名: Watanabe M, Kato J, Inoue I, Yoshimura N, Yoshida T, Mukoubayashi C, Deguchi H, Enomoto S, Ueda K, Maekita T, Yamamichi N, et al
  • 雑誌名: Int J Cancer
• [雑誌論文] Magnifying endoscopy with narrow-band imaging helps determine the management of gastric adenomas. (2012)
  • 著者名/発表者名: Tsuji Y, Ohata K, Sekiguchi M, Ohno A, Ito T, Chiba H, Gunji T, Fukushima J, Yamamichi N, Fujishiro M et al
  • 雑誌名: Gastric Cancer 巻: 15(4) ページ: 414-418
• [雑誌論文] Evaluation of safetyof endoscopic biopsy without cessation of antithrombotic agents in Japan. (2012)
  • 著者名/発表者名: Ono S, Fujishiro M, Kodashima S, Takahashi Y, Minatsuki C, Mikami-Matsuda R, Asada-Hirayama I, Konno-Shimizu M, Tsuji Y, Mochizuki S, Yamamichi N, et al
  • 雑誌名: J Gastroenterol 巻: 47(7) ページ: 770-774
• [雑誌論文] Endoscopic mucosal resection with a ligation device or endoscopic submucosal dissection for rectal carcinoid tumors: an analysis of 24 consecutive cases. (2012)
  • 著者名/発表者名: Niimi K, Goto O, Fujishiro M, Kodashima S, Ono S, Mochizuki S, Asada-Hirayama I, Konno-Shimizu M, Mikami-Matsuda R, Minatsuki C, Yamamichi N, et al
  • 雑誌名: Dig Endosc 巻: 24(6) ページ: 443-447
• [雑誌論文] Prospective single-arm trial of two-week rabeprazole treatment for ulcer healing after gastric endoscopic submucosal dissection. (2012)
  • 著者名/発表者名: Niimi K, Fujishiro M, Goto O, Kodashima S, Minatsuki C, Hirayama I, Mochizuki S, Ono S, Yamamichi N, Kakushima N et al
  • 雑誌名: Dig Endosc 巻: 24(2) ページ: 110-116
• [雑誌論文] Education and Imaging. Gastrointestinal: esophageal hematoma: a rare cause of upper gastrointestinal bleeding. (2012)
  • 著者名/発表者名: Hirano K, Yamamichi N, Fujishiro M, Koike K
  • 雑誌名: J Gastroenterol Hepatol 巻: 27(10) ページ: 1642
• [雑誌論文] Discrepancy in diagnosis of gastric submucosal tumor among esophagogastroduodenoscopy, CT, and endoscopic ultrasonography: a retrospective analysis of 93 consecutive cases. (2012)
  • 著者名/発表者名: Goto O, Kambe H, Niimi K, Mochizuki S, Asada-Hirayama I, Minatsuki C, Ono S, Kodashima S, Yamamichi N, Yamaji Y et al
  • 雑誌名: Abdom Imaging 巻: 37(6) ページ: 1074-1078
• [雑誌論文] Postprandial fullness correlates with rapid inflow of gastric content into duodenum but not with chronic gastritis. (2011)
  • 著者名/発表者名: Yamamichi N, Shimamoto T, Minatsuki C, Yoshida Y, Fujishiro M, Kodashima S, Kato J, Goto O, Ono S, Niimi K et al
  • 雑誌名: BMC Gastroenterol 巻: 11 ページ: 140
• [雑誌論文] An effective training system for endoscopic submucosal dissection of gastric neoplasm. (2011)
  • 著者名/発表者名: Tsuji Y, Ohata K, Sekiguchi M, Ito T, Chiba H, Gunji T, Yamamichi N, Fujishiro M, Matsuhashi N, Koike K
  • 雑誌名: Endoscopy 巻: 43(12) ページ: 1033-1038