| 研究実績の概要 |
We have made excellent progress on all four aims of the grant and published one related manuscript during the last fiscal year. The published work (Adaikkan et al, 2024) focused on local circuit control of feedback inhibition in the CA1 region of the hippocampus, related to aim 1 of the project. Ongoing work on all four aims of the project have been progressing nicely and are summarized in more detail below. Anatomical characterization of the noncanonical circuits in aims 1, 2 and 3 is nearly complete and behavioral, electrophysiological and calcium imaging data is currently beging collected. In addition I have presented various aspects of our research progress at multiple international meetings in Germany, Australia, China, Korea, Singapore and Mexico.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
The work on Aim 1 has gone very smoothly and I anticipate the initial manuscript linking medial septum modulation to learning speed will be published within a year. For Aim2 we have begun in vivo multisite neuropixel 2 recordings in behaving animals and established new useful genetic tools. For Aim 3 we have completed anatomical characterization of layer 5b neurons and identified a behavioral phenotype based on their manipulation. For Aim 4 we continue to refine an optimal behavioral paradigm, however this is expected due to the complexity of the task, and we are now positioned to start the initial manipulation experiments. Overall progress has been excellent.
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