| 研究実績の概要 |
In this study, we investigated the expression profile of a novel B7 checkpoint molecule, ILDR2, and applied various mouse models to clarify the immunological functions of ILDR2 in cancer immunity and neuroimmunity. We aim to deepen our understanding of new immune tolerance induction mechanisms, explore the possibility of systemic immune regulation and develop novel immunotherapy for cancer and autoimmune diseases.By using of experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, the applicant and colleagues has demonstrated that the development of Eomes+ Th cells, which are closely related to disease severity of chronic EAE and SPMS patients, are largely depended on disease associated microglia (DAM)
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| 今後の研究の推進方策 |
We will examine whether administration of ILDR2-Fc into EAE mice could ameliorate disease progress. In addition, we will also evaluate whether disease progression will be accelerated by administration of the neutralizing antibody against ILDR2 into EAE mice. Moreover, the interaction between microglia or astrocyte and Th cells derived from CNS can be evaluated. To evaluate the antigen-specific inhibition of ILDR2, 2D2 TCR transgenic mice that express a myelin oligodendrocyte glycoprotein (MOG)-specific T cell receptor will be used.
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