| 研究実績の概要 |
We have thoroughly making the well-equilibrated Flagellar motors MotA/B of the Bacillus subtilis, Campilobacter Jejuni and Clostridium sporogenes by performing the multiple trials, long molecular dynamics simulation (MD). The MotA/B proteins are embeded on the lipid bilayer membrane alike to the bacteria membrane. After that, we have performed detailed analysis of the ions interacting to the MotA/B proteins. After that, we have used enhanced sampling technique to drive the ions moving from periplasm to cytoplasm. The results help us to distinguish key interaction residues on MotA/B proteins that help ions to go through periplasm to cytoplasm without being trapped.
|
