| 研究課題/領域番号 |
23K14927
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| 研究機関 | 順天堂大学 |
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研究代表者 |
アンディカ クリスティーナ 順天堂大学, 健康データサイエンス学部, 講師 (00965460)
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| 研究期間 (年度) |
2023-04-01 – 2026-03-31
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| キーワード | Glymphatic system / Metabolic sydrome / Marijuana / DTI-ALPS / Free water imaging |
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| 研究実績の概要 |
In the present research project, diffusion magnetic resonance imaging-based measures were applied to evaluate the glymphatic system function. The glymphatic system is a glial-based perivascular network that promotes brain metabolic waste clearance.
Our findings were as follows:
1. Glymphatic system alterations in older adults with metabolic sydrome: we showed reduced glymphatic clearance function in older adults with metabolic syndrome, possibly due to the adverse effects of vascular risk factors on the glymphatic system. Our findings also indicate associations between reduced glymphatic clearance function and elevated diastolic blood pressure, hyperglycemia, smoking habit, and poorer cognitive performance.
2. Glymphatic system alterations in marijuana users: we observed the adverse effects of younger age at first use of marijuana on glymphatic system function, which is associated with impaired working memory and fluid intelligence.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
As planned, data can be collected in a timely manner, and data analysis and paper writing can also proceed according to schedule.
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| 今後の研究の推進方策 |
Data analysis is currently underway to evaluate the relationship between impaired glymphatic system function and changes in brain microstructure.
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| 次年度使用額が生じた理由 |
The budget will be used to pay for purchasing a workstation, as well as covering open access fees, conference participation fees, and English proofreading.
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