| 研究実績の概要 |
.The gut microbiome and oral microbiome can communicate each other through their anatomical connection. Therefore, any alteration in the oral microbiota can affect the gut microbiota and vice-versa. Recently, for the first time, we showed that brain disorder such as psychological stress can affect the oral microbiome in an animal model.
Owing to the communication of oral and gut microbiome and their relation to brain, a three-way microbiota axis “oral-brain-gut” has been proposed. However, very limited studies have been done to determine the role of oral microbiome in the normal functioning of brain. Therefore, we aim to clarify the role of oral microbiome in maintaining normal brain function and the existence of microbiota oral-gut-brain axis using germ-free rodents.
We slightly changed our research plan. Initially, it was planned to study the effect of oral-gut-brain axis in normal brain function. However, it was important to understand how brain diseases such as Alzheimer's diseases could affect the oral and gut microbiome together. Therefore, in the first phase of the experiment, we collected oral swabs and gut stool from the Alzheimer's disease model mice. We are currently working on performing 16SrRNA sequencing of those samples. This will clarify if the oral-gut-brain axis affects the pathology in the brain such as in Alzheimer's disease.
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