| 研究課題/領域番号 |
23K17239
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| 研究機関 | 国立研究開発法人量子科学技術研究開発機構 |
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研究代表者 |
KANG HANGYU 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所 先進核医学基盤研究部, 主任研究員 (90824467)
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| 研究期間 (年度) |
2023-04-01 – 2025-03-31
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| キーワード | Small animal PET / In vivo imaging / High-resolution |
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| 研究実績の概要 |
<Optimization of the crystal and PET geometries>
A Monte Carlo simulation study was performed to find out the optimal crystal geometry in terms of spatial resolution. The optimal crystal geometry has 3-layer staggered depth-of-interaction (DOI) configuration, in which the 1st, 2nd, and 3rd layers have 3 mm, 3 mm, and 5 mm thereby resulting the total thickness of 11 mm. The crystal pitch of 0.8 mm and reflector thickness of 0.1 mm were selected. The optimized PET geometry has an inner diameter of 48 mm, and axial coverage of 23.4 mm.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
1: 当初の計画以上に進展している
理由
<PET geometry optimization>
The crystal and PET geometries were optimized by using the Monte Carlo simulation software in time.The Monte Carlo simulation results were submitted to an international conference, which will be held in the US in 2024.
<Front-end electronics design>
In addition, the signal processing electronics such as front-end boards and amplifier boards were designed, which were originally scheduled on the second fiscal year. The front-end readout boards and amplifier boards were designed by using Altium Designer software. The developed front-end and amplifier boards were working properly.
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| 今後の研究の推進方策 |
<Optimization of a detector>
We plan to optimize the front-end and amplifier boards to improve the detector performance in terms of energy resolution and timing resolution.
<Develop a prototype PET scanner>
We plan to develop a prototype full-ring PET system with the optimized front-end electronics.The performance of the full-ring PET system will be evaluated with the NEMA-NU4 protocol and resolution phantom imaging.
In addition, we plan to perform in vivo mouse brain imaging with the developed PET scanner.
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| 次年度使用額が生じた理由 |
The crystals were not purchased due to the internal budget usage deadline of QST.
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