| 研究課題/領域番号 |
23K19456
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| 研究機関 | 山口大学 |
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研究代表者 |
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| 研究期間 (年度) |
2023-08-31 – 2025-03-31
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| キーワード | HAP1 / steroid / Brain / rodent |
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| 研究実績の概要 |
Our previous in vitro findings suggest that STB/HAP1 could be related to the subcellular regulation of SHRs. In this research project to clarify the in vivo effects of STB/HAP1 in regulating or protecting the functions of sex steroids via their receptors; AR and ER, I examined the detailed in vivo immunohistochemical relationships of HAP1 with AR, and ER in the preoptic area and hypothalamic areas in adult mice. I found that HAP1 was highly coexpressed with both the sex steroid receptors in the different brain regions, which is suggestive of HAP1 modification of the steroidal functions in the brain.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
I have completed my first objective, clarifying the in vivo relationships of STB/HAP1 with different steroid receptors. I have presented my research findings at several academic conferences.
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| 今後の研究の推進方策 |
1. Assessments of effects of STB/HAP1 on serum hormone concentration.
2. Examination of effects of STB/HAP1 on the number of SHR-immunoreactive neurons.
3. Clarification of the effects of STB/HAP1 and steroid hormone-related functions.
4. Action if the research has yet to progress as planned initially.
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| 次年度使用額が生じた理由 |
In the present study, I am using knockout mice. The process of getting genetically modified mice was delayed due to the insufficient pregnancy rate of the mice.
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