| 研究実績の概要 |
The goal of the research for year 2021 (R 3) was defined as theoretical calculation, design, and optimization; construction of the components, experimental models, evaluation; and high-speed microscopic setups.
According to the plan, we performed theoretical calculation to optimize the volume of the vaccine/drug to be delivered with size of the needle-free shock wave injector. Based on the calculations, parts were designed. Design and construction of electrodes, diaphragms, and nozzles for nanosecond-pulsed-electric-field induced cavitation/shock wave streaming micro-injector were performed. Highly magnified shadowgraph and schlieren optical setups with single wavelength bandpass filter and laser as light source for ultra-high-speed visualizations were constructed. The flow physics, plasma, cavitation and microstreaming after nanosecond electric discharge near electrodes were observed. We also constructed a high-speed microscopic setup and performed micro-particle tracking to evaluate speed of the micro-flow filed in skin and tissue/tumor models.
To increase efficiency of the microjet delivery, we took an innovative approach by synthesizing keratin protein nanoparticles for conjugating with the vaccine/drug, which significantly enhances the delivery with minimum amount of the vaccine/drug to reduce the cost.
The obtained results were evaluated for publication.
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| 今後の研究の推進方策 |
Based on progress achieved during year 2021 (R 3), measures have been taken for the research to advance as planned. With improvements over the coronavirus restrictions, the research is expected to advance smoothly. Further publication, international conference presentation, and international collaborations have been planned.
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