研究課題/領域番号 |
22H03922
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配分区分 | 補助金 |
研究機関 | 千葉大学 |
研究代表者 |
ゴメスタメス ホセデビツト 千葉大学, フロンティア医工学センター, 准教授 (60772902)
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研究分担者 |
大鶴 直史 新潟医療福祉大学, リハビリテーション学部, 教授 (50586542)
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研究期間 (年度) |
2022-04-01 – 2025-03-31
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キーワード | Brain stimulation / Neural Engineering / Medical Imaging / Computational Biophysics / Interferential |
研究実績の概要 |
Based on the aim of developing a personalized computational physical model for focal and deep brain stimulation, we investigated stimulation dose characteristics using a combined approach of numerical and experimental techniques. The experiments showed the possibility of focal stimulation of individual hand fingers that are condensed in a small area of the brain demonstrating focality with high resolution. In addition, new insight into the dual-hemisphere transcranial stimulation application was presented for deep cortical stimulation of the lower limb. Finally, progress in the development of a micro-physical neuron model integrated with the personalized brain stimulation simulator was achieved to investigate interferential phenomena.
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現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
The developed personalized computational physical model for investigating focal and deep brain stimulation characteristics is in place. Simulation and experiments were conducted showing the feasibility of focal and deep stimulation providing a better understanding of the characteristics of the generated electric currents in the brain in terms of focality and depth. The model integrated the micro-physical brain neuron to investigate independent kilohertz stimulation and a combination of two-kilohertz stimulation (i.e., interferential stimulation) for further characterization of deep and focal brain stimulations. Publications in recognized journals and top conferences in the field demonstrate the progress of the work.
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今後の研究の推進方策 |
In FY2023, the multiscale electrophysiological model will be further improved and validated to investigate focal and deep stimulation. For validation, we will conduct an extended revision of stimulation parameters to achieve personalized focal stimulation. Further, the mechanism of stimulation of kilohertz electric currents (including interferential) will be investigated based on simulations together with experimental measurements. The original plan included brain stimulation at kilohertz currents but they became prohibitive considering the required high electric currents in the brain for evoked responses in recent reports (Wang et.al., 2023, Neural Eng). In substitution, mechanisms of kilohertz stimulation will be investigated in experiments of the peripheral nervous system.
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