| 研究課題/領域番号 |
23H01146
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| 配分区分 | 補助金 |
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| 研究機関 | 沖縄科学技術大学院大学 |
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研究代表者 |
PIGOLOTTI Simone 沖縄科学技術大学院大学, 生物複雑性ユニット, 教授 (30812193)
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| 研究期間 (年度) |
2023-04-01 – 2026-03-31
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| キーワード | DNA replication / replisome / bacterial cell cycle |
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| 研究実績の概要 |
During this FY, we achieved two main goals of our project. The first goal has been to develop a general theory to describe the DNA abundance distribution from the genome replication dynamics. This general theory constitutes the basis of our approach. The paper based on this theory has been published in Plos Computational Biology. The second goal has been to startup our wet lab activity and successfully run the first benchmark experiments on E.coli. This success puts us in a very good position for completing the rest of the project.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
The research is progressing as planned, with one paper already published and the groundwork for future experimental activity already done. We expect to soon make progress on applying our theory and experiment to novel systems, in particular to E.coli mutants and other microbial species, as detailed in the proposal of this project.
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| 今後の研究の推進方策 |
During this fiscal year, we expect to finalize our project on studying DNA replication in engineered E.coli strains with multiple origins of replication. Motivated by our recent theoretical results, we will also apply our method to budding yeast, to prove that our approach is not limited to prokaryotic species. We expect to obtain at least preliminary results on this second goal during this fiscal year.
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