| 研究課題/領域番号 |
23H02864
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| 配分区分 | 補助金 |
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| 研究機関 | 福島県立医科大学 |
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研究代表者 |
織内 昇 福島県立医科大学, 公私立大学の部局等, 教授 (40292586)
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| 研究分担者 |
趙 松吉 福島県立医科大学, 公私立大学の部局等, 教授 (80374239)
関亦 明子 福島県立医科大学, 看護学部, 教授 (50321823)
右近 直之 福島県立医科大学, 公私立大学の部局等, 講師 (70792985)
小島 祥敬 福島県立医科大学, 医学部, 教授 (60305539)
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| 研究期間 (年度) |
2023-04-01 – 2026-03-31
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| キーワード | targeted α therapy / 211At-PSMA / radiation sialadenitis / salivary gland / SNARE proteins / prostate cancer / xerostomia |
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| 研究実績の概要 |
The goal of this study is to elucidate the mechanism of salivary gland uptake of 211At-labeled compounds from a molecular and pathological perspective, and to develop a treatment for xerostomia caused by salivary gland disorders.
By evaluating the specific uptake and off-target uptake of the 211At-PSMA ligand into the salivary glands of normal mice, we clarify the molecular mechanism of uptake in relation to receptors such as the involvement of SNARE proteins, and obtain knowledge that leads to the treatment of salivary gland disorders, including xerostomia and the relationship with taste disorders.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
3: やや遅れている
理由
The aim of the present study is to clarify the mechanism by which 211At-PSMA ligands accumulate in the salivary glands by elucidating a molecule involved in the transport of 211At-PSMA ligands in the salivary glands, and to develop a preventive method for radiation sialadenitis due to 211At-PSMA ligands therapy. We will quantitatively evaluate the specific uptake and off-target uptake of 211At-PSMA ligand into the salivary glands of normal mice and clarify the molecular mechanism of 211At-PSMA ligand uptake in relation to receptors such as the involvement of SNARE proteins and obtain knowledge that will lead to the treatment of salivary gland disorders.
We have established the study protocol of quantitative evaluation of specific and non-specific uptake of the 211At-PSMA ligand administered to normal mice by removal of salivary glands and pathological analysis to clarify the relationship between the absorbed dose of the salivary glands and pathological tissue damage and salivation. The relationship between the absorbed dose estimated from the accumulation of 211At-PSMA ligands and the amount of salivation will be clarified. Images of HE staining of the submandibular gland taken from mice treated with 211At-PSMA ligands with and without inhibition will be obtained to examine pathological contrast to the state of inflammation and the histological damage.
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| 今後の研究の推進方策 |
According to the protocol as described above, the animal study will be performed to identify molecules involved in receptor binding of 211At-PSMA ligands and confirm inhibition of uptake by knockdown of identified molecules, then obtain knowledge leading to the treatment of salivary gland dysfunction due to radiation sialadenitis.
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