| 研究課題/領域番号 |
23H03740
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| 配分区分 | 補助金 |
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| 研究機関 | 九州大学 |
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研究代表者 |
LI JUNJIE 九州大学, 先導物質化学研究所, 准教授 (80869892)
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| 研究分担者 |
田中 賢 九州大学, 先導物質化学研究所, 教授 (00322850)
小林 慎吾 九州大学, 先導物質化学研究所, 特任准教授 (70625110)
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| 研究期間 (年度) |
2023-04-01 – 2026-03-31
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| キーワード | enzyme delivery / polymer / nanoreactor / oxidation therapy |
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| 研究実績の概要 |
This proposal aims to develop a simple delivery system for enzyme therapy. This polymer delivery system can synchronize long circulation in blood, precise clearance and degradation by macrophage, and enzyme activation in tumor. Some polymers have been prepared for enzyme delivery. We have tried to encapsulate the enzyme (such as glucose oxidase) and evaluated the cytotoxicity. We have performed some preliminary experiments for in vivo blood circulation and toxicity.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
The project progress smoothly.
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| 今後の研究の推進方策 |
We will perform the detailed cell experiments (such as cytotoxicity) and in vivo animal experiments (such as blood circulation, biodistribution, safety, and antitumor effect).
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