| 研究課題/領域番号 |
24570150
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| 研究機関 | 名古屋大学 |
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研究代表者 |
MATURANA ANDRES 名古屋大学, 生命農学研究科, 准教授 (10452004)
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| キーワード | 細胞内シグナル / Zでぃすく / 足場タンパク質 |
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| 研究概要 |
Our aim is to study the function of the PDZ-LIM protein ENH1 in the development of cardiac hypertrophy. ENH alternative splice variants have an opposite function than ENH1 in the heart. ENH splice variants prevent the cardiac hypertrophy while ENH1 promote cardiac hypertrophy. Therefore, we also aim at resolving the mechanisms of ENH1 expression and alternative splicing.
In this fiscal year, we identify two splicing factors essential for the mechanisms of enh gene splicing. By altering their expression we could modify the expression of ENH splice variants. In addition we confirmed that ENH1 LIM regions interact with the transcription factor CREB and localized at specific nuclear regions.
Our research led to the publication of one paper and several presentation in national and international meetings. And we are now preparing another publication to be submitted.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
2: おおむね順調に進展している
理由
Our work lead to one publication last year and we are preparing another manuscript for submission.
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| 今後の研究の推進方策 |
We proceed the research as planned.
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| 次年度の研究費の使用計画 |
We have planned to generate a transgenic mice but experimental problems have delayed our plan, we are planning to generate the transgenic mice in the next fiscal year.
The amount incurred in the next fiscal year is planned to be used to generate a transgenic mice.
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