| 研究分担者 |
坪倉 卓司 京都府立医科大学, 医学(系)研究科(研究院), 助教 (50347465) [辞退]
小林 加奈 高知大学, 医学部附属病院, 講師 (70433282) [辞退]
相部 則博 京都府立医科大学, 医学(系)研究科(研究院), 助教 (50739240)
中村 聡明 京都府立医科大学, 医学(系)研究科(研究院), 講師 (60420452) [辞退]
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| 研究実績の概要 |
We analyzed the levels of exhaled nitric oxide (eNO) and serum surfactant protein D (SP-D) during and after 34 thoracic radiotherapy (RT) sessions in 33 patients. We measured eNO levels before RT, every week during RT, just after the treatment, and 1, 3, 6, 9, and 12 months after the treatment. The therapy reduced the eNO from 24.3 ppb ± 12.8 ppb before RT to 19.0 ± 10.4 ppb just after RT (p = 0.04). Five patients (14%) developed symptomatic RP of grade 2 or higher, 3 - 5 months later, with an elevation in the eNO ratio of 2.1 ± 0.68-fold the minimum value. The RP-negative group showed up to 1.4 ± 0.6-fold elevation (p = 0.02). No predictive changes in eNO levels were observed before the onset. RT elevated serum SP-D level at 3 - 6 months after RT. There was a statistically significant difference between previous serum SP-D level between RP positive and negative patients.
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