| 研究概要 |
The purpose of the research was the creation of new molecular release systems capable of remotely deliver biologically active molecules under light irradiation.
To this end, our idea was to combine the high storage ability of porous coordination polymers (PCPs), a new class of crystalline materials assembled by organic linkers and inorganic joints at the molecular scale with the photo-thermal properties of gold nanorods (GNRs) into designed mesoscopic composite materials. These new composite platforms were synthesized by applying a method developed in the applicant's group, so-called "coordination-replication", which enables to precisely control the PCP crystallization location through a dissolution-recrystallization process.
Delicate core－shell structures composed of an individual GNR core and an aluminum-based PCP shell, were thus achieved by the selective deposition of an aluminum precursor onto the surface of GNR followed by the replication of the precursor into aluminum-based PCPs.
The creation of such mesoscopic structures resulted in the implementation of unique motion-induced molecular release, triggered by the highly efficient conversion of optical energy into heat that occurs when the GNRs are irradiated into their plasmon band. Temporal control of the molecular release was demonstrated with anthracene as a guest molecule (priorly immobilized within the pores of the PCP shell) and fluorescent probe by means of fluorescence spectroscopy.
These new core-shell systems are now investigated as platforms for the release of glutamic acid and hydrogen sulfide.
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