| 研究実績の概要 |
To verify the existence of the CKD-resistant loci on Chr 2 from the B6 mouse, we produced ICGN congenic mice homozygously introgressed Chr 2 from the B6 mouse using marker-assisted backcrossing. ICGN mice showed low Hb and low Ht, indicating significant renal anemia. On the other hand, the erythrocytic parameters of the congenic mice were normal levels as well as control mice. Both ICGN and congenic mice mice developed proteinuria up to 8 week old, but the urinary albumin excretion in congenic mice was lower than that of ICGN mice). In the histopathologic analysis of the kidney sections,congenic mice showed milder phenotypes than ICGN mice. These results confirmed the existence of the CKD-resistant/susceptible locus on Chr 2.
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