| 研究課題/領域番号 |
25430184
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| 研究機関 | 慶應義塾大学 |
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研究代表者 |
SELVARAJOO Kumar 慶應義塾大学, 政策・メディア研究科, 特任准教授 (40439253)
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| 研究期間 (年度) |
2013-04-01 – 2016-03-31
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| キーワード | Cancer / Computational Model / Systems Biology / TRAIL / PKC |
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| 研究実績の概要 |
The cancer research using our systems biology approach has been successfully. We validated our model predictions where we identified PKC-delta as a key co-target to optimise TRAIL-stimulated cancer apoptosis. Our results has been published:
Hayashi K, Tabata S, Piras V, Tomita M & Selvarajoo K,‘Systems Biology Strategy Reveals PKC-delta is Key for Sensitizing TRAIL-Resistant Human Fibrosarcoma’(2015) Front. Immunol.; 5:659.
and appeared in Yamagata Shimbun on 14 Jan 2015 Shonai Nippo and 15 Jan 2015.
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| 現在までの達成度 (区分) |
現在までの達成度 (区分)
1: 当初の計画以上に進展している
理由
We have been successful with our goals.
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| 今後の研究の推進方策 |
Planning to perform more modeling work and some other experiments on different cancer cells with TNF
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| 次年度使用額が生じた理由 |
The same difference is due to less usage considering tight budget.
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| 次年度使用額の使用計画 |
More simulations and experiments can be done. Furthermore, some part of the money is used to invited two world renowned scientist for the 2nd Symposium on Complex Biodynamics and Networks, which I am chairing.
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| 備考 |
This is the website of an international conference which I chaired, and some part of the grant money has used to invited 2 keynote speakers (Leroy Hood and Shizuo Akira).
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