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2015 年度 実績報告書

Enhancing apoptosis of cancers using systems biology approach.

研究課題

研究課題/領域番号 25430184
研究機関慶應義塾大学

研究代表者

Selvarajoo Kumar  慶應義塾大学, 政策・メディア研究科, 准教授 (40439253)

研究期間 (年度) 2013-04-01 – 2016-03-31
キーワードTRAIL / Cancer / Computational Model / Apoptosis / Tumor Immunology
研究実績の概要

Over the last decade, our research team has investigated the dynamic responses and global properties of living cells using systems biology approaches. For this project, we focused on overcoming cancer resistance. TRAIL (tumor necrosis factor related apoptosis-inducing ligand), a proinflammatory cytokine, has shown promising success in controlling cancer threat due to its ability to induce apoptosis in cancers specifically, while having limited effect on normal cells. Nevertheless, several malignant cancer types, such as fibrosarcoma (HT1080) or colorectal adenocarcinoma (HT29), remain non-sensitive to TRAIL. To sensitize HT1080 to TRAIL treatment, we developed a dynamic computational model based on perturbation-response approach, to predict a crucial co-target to enhance cell death. The model simulations suggested that PKC inhibition together with TRAIL induce 95% cell death. Subsequently, we confirmed this result experimentally utilizing the PKC inhibitor, bisindolylmaleimide (BIM) I, and PKC siRNAs in HT1080.

  • 研究成果

    (4件)

すべて 2015

すべて 雑誌論文 (1件) (うち査読あり 1件、 オープンアクセス 1件、 謝辞記載あり 1件) 学会発表 (2件) (うち国際学会 2件、 招待講演 1件) 学会・シンポジウム開催 (1件)

  • [雑誌論文] Can the Second Law of Thermodynamics Hold in Cell Cultures?2015

    • 著者名/発表者名
      Selvarajoo K
    • 雑誌名

      Front. Genet.

      巻: 6 (2015) ページ: 262

    • DOI

      10.3389/fgene.2015.00262

    • 査読あり / オープンアクセス / 謝辞記載あり
  • [学会発表] Overcoming Cancer Treatment Resistance using Systems Biology Approaches.2015

    • 著者名/発表者名
      Selvarajoo K
    • 学会等名
      The MGMS conference: Exploring Mechanisms in Biology
    • 発表場所
      Bioinformatics Institute(Singapore)
    • 年月日
      2015-11-25 – 2015-11-27
    • 国際学会 / 招待講演
  • [学会発表] Self-Organization of Cancer Cells is Key for Overcoming Therapeutics.2015

    • 著者名/発表者名
      Selvarajoo K
    • 学会等名
      1st International Conference on Computational Modeling of Metabolic Health, Inflammation and Diabetes MMH 2015
    • 発表場所
      University of Cambridge(Cambridge,UK)
    • 年月日
      2015-10-06 – 2015-10-07
    • 国際学会
  • [学会・シンポジウム開催] 2nd Symposium on Complex Biodynamics & Networks2015

    • 発表場所
      Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata
    • 年月日
      2015-05-11 – 2015-05-13

URL: 

公開日: 2017-01-06  

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