| 研究概要 |
The purpose of the present study is to investigate the role of Gremlin focused on tumor angiogenesis in pituitary adenoma.
Double fluorescence immunohistochemistry of Gremlin and CD34 to elucidate distribution in pituitary adenoma tissues obtained by transsphenoidal surgery in 45 cases (7 PRL-oma, 17 GH-oma, 17, 2 ACTH-oma, and 2 TSH-oma). Expression of CD34-positve vessels was significantly co-related to that of Gremlin. Co-localization of Gremlin and CD34 was statistically significant. Subsequently, Gremlin and microvascular density (MVD) were detected by double-immunofluorescence microscopy in CD34-positive vessels from tissue microarray analysis in 61 cases with pituitary adenomas. In tissue microarray analysis, MVD were significantly increased along with increased Gremlin. Meanwhile, adenoma subtype and Knosp grading were not related to Gremlin.
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