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2014 年度 実績報告書

A novel, non-invasive, MRI based approach to the measurement of OEF, CBF and CMRO2 in the human brain.

研究課題

研究課題/領域番号 25861120
研究機関岩手医科大学

研究代表者

ジョナサン グッドウィン  岩手医科大学, 医学部, 研究員 (80633156)

研究期間 (年度) 2013-04-01 – 2015-03-31
キーワードSWI / OEF / CBF / CMRO2 / Look Locker / Multi Banding / 7T / 3T
研究実績の概要

The development of an image processing protocol, which allows region specific measurement of OEF in the human brain, was developed and published in the Journal of Neuroimaging.
Subsequent efforts focused on the development of an ASL imaging technique for cerebral blood flow (CBF) and when combined with OEF images; the subsequent measurement of cerebral metabolic rate of oxygen (CMRO2).
Due to a number of technical limitations on the 7T MRI system, ASL imaging was not successfully performed and therefore CBF and CMRO2 values could not be measured. Instead, the research focus changed to that of a novel ASL technique for 3T scanning. This work we tested SWI and ASL using Look locker readout with multi-banding. We discovered a number of limitations with this approach due to the complexity of image reconstruction. However, this collaborative work is ongoing and will hopefully lead to fruitful results later this year.

  • 研究成果

    (2件)

すべて 2014

すべて 雑誌論文 (1件) (うち査読あり 1件、 オープンアクセス 1件、 謝辞記載あり 1件) 学会発表 (1件)

  • [雑誌論文] Susceptibility-Weighted Phase Imaging and Oxygen Extraction Fraction Measurement during Sedation and Sedation Recovery using 7T MRI2014

    • 著者名/発表者名
      Jonathan A. Goodwin, Kohsuke Kudo, Yutaka Shinohe, Satomi Higuchi, Ikuko Uwano, Fumio Yamashita and Makoto Sasaki
    • 雑誌名

      Journal of Neuroimaging

      巻: 00 ページ: 1-7

    • DOI

      10.1111/jon.12192

    • 査読あり / オープンアクセス / 謝辞記載あり
  • [学会発表] In vivo tumour extracellular pH monitoring using electron paramagnetic resonance: the effect of X-ray irradiation.2014

    • 著者名/発表者名
      Goodwin J, Yachi K, Nagane M, Yasui H, Miyake Y, Inanami O, Bobko AA, Khramtsov VV, Hirata H.
    • 学会等名
      ISMRM
    • 発表場所
      Milan, Italy
    • 年月日
      2014-05-10 – 2014-05-16

URL: 

公開日: 2016-06-01  

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