| 研究実績の概要 |
Oil bodies and peroxisomes are the central players for lipolysis and sucrose production. Their physical interaction is expected to play an important role during lipid metabolism in all eukaryotes. In this study, we first characterized the physiological interaction between oil bodies and peroxisomes and found that oil bodies and peroxisomes enhance physical interactions with each other to enhance lipolysis when the sucrose is limited in the cells. Second, we identified an Arabidopsis mutant, sdp1, which is defective in lipolysis and sucrose production, showing enhanced oil body-peroxisome interaction throughout seed germination. By analyzing sdp1 mutant, we found that sucrose acts as a negative signal to suppress the oil body-peroxisome interaction. We also identified an anchor protein, PED3, that is directly involved in the membrane tethering of oil bodies and peroxisomes. These findings reveal a novel mechanism on the regulation of oil body-peroxisome communication, which is used by the cells to control cellular sucrose homeostasis upon environmental signal. It provides potential targets on the future application and biological approach on increasing plant yield of oils.
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