| 研究実績の概要 |
The goal of this grant was to prepare and test gold nanoparticles for potential biosensing applications. To address thiol-instability, we sought to increase stability by employing bidentate NHC ligands functionalized with long alkyl chains to block the surface. All nanoparticles prepared employing non-alkylated NHCs aggregated in solution within a week. By comparison, nanoparticles protected with alkylated NHCs survived heating to 130 C in xylene for 24 hrs.
All of the nanoparticles prepared by the top down approach provided more stable nanoparticles than those made with ligand exchange methods. The greater stability of nanoparticles prepared by the top-down method may be attributed to a higher NHC concentration on the surface. Regardless, this work represents the most stable NHC Au nanoparticles prepared to date and water-soluble versions are currently being prepared for use in vivo.
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