| 研究成果の概要 |
D-serine is an endogenous D-amino acid abundant in the mammalian brain. The main target of D-serine is the NMDA receptor, which has important roles in learning, memory and neurodegenerative diseases. However, how D-serine is regulated in the brain still remains to be clarified. Here we have revealed that y+Asc-1 is a neuron specific D-serine transporter and involved in the neuron-derived D-serine release in the brain. Our findings would provide a new insight into the neural D-serine study and contribute to the understanding of D-serine function in the brain.
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