| 研究実績の概要 |
In order to identify novel TSPO ligands that exhibit desirable AD-biomarker outcomes, the steroidogenic efficacy and acute behavioral effects of three new generation TSPO ligands, CLINDE, PBR175, and PBR162, was evaluated in mice. CLINDE, which exhibited the most favorable behavioral and pharmacokinetic profile, was investigated further for its specificity and binding affinity in human brain. These findings indicate that the new generation TSPO imidazopyridine ligands, CLINDE, PBR-175 and PBR162 rapidly promote neurosteroidogenesis, thereby enhancing learning and memory function in vivo. These second generation TSPO ligands are promising therapeutic candidates with improved pharmacokinetic properties compared classic TSPO ligands.
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