| 研究実績の概要 |
- We measured soluble MICA protein by ELISA.
- Of the 4 SNPs analysed, MICA, DEPDC5, HCP5, and PNPLA3, only the MICA genotypes were significantly associated with development of HCC (p = 0.0185). The major (MA), hetero (HE), and minor (MI) genotypes occurred in 40%, 41%, and 19% of HCC patients and in 43%, 47%, and 10% of non-HCC patients, respectively. Interestingly, the MICA genotype was significantly correlated with soluble MICA protein levels.
- We have submitted manuscript "Polymorphisms in MICA, but not in DEPDC5, HCP5 or PNPLA3, are associated with chronic hepatitis C-related hepatocellular carcinoma" to journal Scientific Reports. We are waiting for the decision.
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