公募研究
In Heisei 27 we have made great progress. We aimed to map anatomical pathways from the midbrain periaqueductal gray (PAG) to the amygdala through which aversive information could produce fear learning. Using viral tracing we identified specific pathways from dorsal and ventral PAG through the centromedial and paraventricular nuclei of the thalamus to the lateral amygdala. We also found that optogenetic manipulation of different parts of this pathway had distinct effects on fear learning.In addition to examining the pathway to the amygdala from the PAG we also examined how prediction errors are encoded in the PAG and LA. We found that neurons in the dorsal PAG subregion encode prediction errors that are affected by manipulations of a feedback from central nucleus of the amygdala to the ventral PAG. We then examined how feedback from the central nucleus of the amygdala (CeA) provides feedback to control prediction error coding. To do this we performed electrophysiological recordings in vlPAG neurons in awake behaving anmials. We found that auditory predictive cues activate a specific population of vlPAG neurons and that this activation was dependent on inputs from the CeA.
2: おおむね順調に進展している
everything proceeded smoothly
In the next fiscal year we will more carefully define the functional contribution of different parts of the PAG-thalamus-lateral amygdala pathway. In addition, we will continue examining how negative feedback produces prediction error coding in dorsal PAG neurons.
すべて 2016 2015
すべて 雑誌論文 (3件) (うち国際共著 3件、 査読あり 3件、 謝辞記載あり 2件、 オープンアクセス 1件) 学会発表 (3件) (うち国際学会 1件、 招待講演 3件)
Nature Neuroscience
巻: In press ページ: In press
10.1038/nn.4308
Pain
巻: 157(1) ページ: 166-173
10.1097/j.pain.0000000000000344
Learning & Memory
巻: 22 ページ: 444-451
10.1101/lm.037283.114
