Hypothalamic control of hippocampal action selection

2017 年度 実績報告書

• 研究領域: 行動適応を担う脳神経回路の機能シフト機構
• 研究課題/領域番号: 17H05591
• 研究機関: 国立研究開発法人理化学研究所
• 研究代表者: McHugh Thomas 国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (50553731)
• 研究期間 (年度): 2017-04-01 – 2019-03-31
• キーワード: supramammillary nucleus / hippocampus / social behavior / spatial behavior / optogenetics

研究実績の概要

During the last fiscal year we have completed the majority of work proposed, including anatomical and immediate-early gene activation characterization of the circuit and electrophysiological recordings. The first manuscript reporting these findings is nearly completed and will be submitted within the coming months. In it we report that we have found that the anatomically and physiologically distinct parallel projections from the supramammillary nucleus (SuM) of the hypothalamus to the CA2 and dentate gyrus (DG) hippocampal regions differentially modulate cognition in a task specific manner. Employing immediate-early gene expression labeling, optogenetics and in vivo recordings in a newly developed SuM-Cre transgenic mouse line we find that the SuM to DG circuit is preferentially engaged by spatial novelty while the neurons targeting CA2 are activated by social novelty. As a result, photoinhibition of the SuM-DG projections leads to deficits in recognizing contextual change while photostimulation of the SuM-CA2 circuit impairs the expression of social memory. These data demonstrate that the hypothalamus can play a task-specific role in the encoding and expression of hippocampal memory.

現在までの達成度 (区分)

1: 当初の計画以上に進展している

理由

The work has gone very smoothly and several manuscripts are in preparation, including one to be submitted shortly. In addition the support of this grant to the project helped fund a paper published in Science in January 2018.

今後の研究の推進方策

In the coming year we will extend our studies of the SuM to examine the role of the SuM to medial septum in the regulation of theta oscillations and the performance of spatial working memory tasks.

研究成果

• [雑誌論文] Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics (2018)
  • 著者名/発表者名: Shuo Chen, Adam Z. Weitemier, Xiao Zeng, Linmeng He, Xiyu Wang, Yanqiu Tao, Arthur J.Y. Huang, Yuki Hashimotodani, Masanobu Kano, Hirohide Iwasaki, Laxmi Kumar Parajuli, Shigeo Okabe, Daniel B. Loong Teh, Angelo H. All, Iku Tsutsui-Kimura, Kenji F. Tanaka, Xiaogang Liu, Thomas. J. McHugh
  • 雑誌名: Science 巻: 359 ページ: 679-684
  • DOI: 10.1126/science.aaq1144
  • 査読あり / 国際共著
• [学会発表] Divergent Information Routing by a Hypothalamo-Hippocampal Circuit During Spatial and Social Memory (2017)
  • 著者名/発表者名: Linmeng He, Shuo Chen, Marie E. Wintzer, Yanqiu Tao, Hiroshi Hama, Kana Namiki, Atsushi Miyawaki, Roman Boehringer, Denis Polygalov, Arthur J.Y. Huang, Thomas J. McHugh
  • 学会等名: Japan Neuroscience Society
  • 国際学会