研究実績の概要 |
Using chemogenetic manipulation and in vivo electrophyiological recording we discovered that transient inhibition of pyramidal cell activity in the CA2 region results in a loss of temporal and informational precision of hippocampal replay. We observed that with this manipulation often discrete memories were inappropriately reactivated at the same time, possibly reflecting the disordered thoughts in the schizophrenic brain and strengthening our hypothesis that CA2 is a key region to examine in this disorder. This work was published in 2021 in Neuron (He et al, doi: 10.1016/j.neuron.2021.08.034.) In addition we have established all the necessary behavioral paradigms and experimental techniques to extend these studies into social based behaviors. These include optogenetic approaches, viral stocks, and high density recording in mice performing social tasks.
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