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2023 年度 実績報告書

Optimal wound healing in a hybrid mechanochemical model

公募研究

研究領域情報物理学でひもとく生命の秩序と設計原理
研究課題/領域番号 22H04841
研究機関東京大学

研究代表者

Schnyder Simon  東京大学, 生産技術研究所, 特任助教 (50812616)

研究期間 (年度) 2022-04-01 – 2024-03-31
キーワードoptimal control / collective behavior
研究実績の概要

I set out to study how wound healing can be interpreted as a process of collective behavior which has evolved to be optimal, as in optimizing a utility function.
However, it became necessary to study the control theoretic approach of the project in a more contained situation and I identified the study of epidemics as a suitable target, both for its general importance as a subject and its reduced simulation complexity as compared to a full tissue simulation.
In two studies, we studied social distancing behavior of populations as it arises from individuals optimizing their own decisions, balancing infection costs with the costs of avoiding contacts with others, e.g. worsening their economic situation or psychological health. We studied how social distancing is affected by the expectation of a vaccination: People social distance more strongly the earlier they expect a vaccine to arrive and the more certain they are about its early arrival time. We also showed how social distancing is affected by limited capacity in the healthcare system. Finally, we demonstrated how governments can design incentives to help individuals make optimal decisions.
I hope that these findings will affect how governments communicate about the state of an epidemic, vaccination development, and that it will help design better government interventions in future epidemics. I hope that this will also transfer into additional understanding of optimal collective behavior in other systems such as cellular tissues.

現在までの達成度 (段落)

令和5年度が最終年度であるため、記入しない。

今後の研究の推進方策

令和5年度が最終年度であるため、記入しない。

  • 研究成果

    (8件)

すべて 2024 2023

すべて 雑誌論文 (2件) (うち国際共著 2件、 査読あり 2件、 オープンアクセス 2件) 学会発表 (6件) (うち国際学会 3件)

  • [雑誌論文] Rational social distancing in epidemics with uncertain vaccination timing2023

    • 著者名/発表者名
      Schnyder Simon K.、Molina John J.、Yamamoto Ryoichi、Turner Matthew S.
    • 雑誌名

      PLOS ONE

      巻: 18 ページ: e0288963

    • DOI

      10.1371/journal.pone.0288963

    • 査読あり / オープンアクセス / 国際共著
  • [雑誌論文] Rational social distancing policy during epidemics with limited healthcare capacity2023

    • 著者名/発表者名
      Schnyder Simon K.、Molina John J.、Yamamoto Ryoichi、Turner Matthew S.
    • 雑誌名

      PLOS Computational Biology

      巻: 19 ページ: e1011533

    • DOI

      10.1371/journal.pcbi.1011533

    • 査読あり / オープンアクセス / 国際共著
  • [学会発表] Self-organised collective social distancing in epidemics2024

    • 著者名/発表者名
      Simon K. Schnyder
    • 学会等名
      8th Regional Conference of the “Grant-in-Aid for Scientific Research on Innovative Areas”
  • [学会発表] Role of the Cell Cycle in Collective Cell Dynamics2024

    • 著者名/発表者名
      Simon K. Schnyder
    • 学会等名
      8th Regional Conference of the “Grant-in-Aid for Scientific Research on Innovative Areas” Research Project “Information physics of living matters”
  • [学会発表] Cell colony dynamics and competition in a hybrid mechanochemical model2023

    • 著者名/発表者名
      Simon K. Schnyder
    • 学会等名
      7th International Soft Matter Conference
    • 国際学会
  • [学会発表] Role of the cell cycle in collective cell dynamics2023

    • 著者名/発表者名
      Simon K. Schnyder
    • 学会等名
      28th International Conference on Statistical Physics (STATPHYS28)
    • 国際学会
  • [学会発表] Role of the Cell Cycle in Collective Cell Dynamics2023

    • 著者名/発表者名
      Simon K. Schnyder
    • 学会等名
      7th Regional Conference of the “Grant-in-Aid for Scientific Research on Innovative Areas” Research Project “Information physics of living matters”
  • [学会発表] Rational social distancing policy during epidemics with limited healthcare capacity2023

    • 著者名/発表者名
      Simon K. Schnyder
    • 学会等名
      Satellite Meeting of the 28th International Conference on Statistical Physics (STATPHYS28) on “Statistical Physics and Information-Processing in Living Systems”
    • 国際学会

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公開日: 2024-12-25  

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