| 研究実績の概要 |
The purpose of this research is the development of new spirobipyridine ligands and of reaction conditions for the efficient and site-selective catalytic functionalization of arenes. During FY2023, we performed a mechanistic study by computations and an unprecedented ligand kinetic isotope effect to prove that a noncovalent interaction between a C-H bond of the spirobipyridine ligand's backbone and the pi electrons of the arene substrate can accelerate the iridium-catalyzed activation of arenes.
We also developed spirobipyridine ligands bearing hydroxyl (OH) groups capable of recognizing pyridine substrates through hydrogen bonding, and both accelerate and control the site selectivity in iridium-catalyzed borylation.
Finally, we developed a spirobipyridine ligand that enables meta-selective iridium-catalyzed silylation of monosubstituted arenes.
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