| 研究領域 | グリアデコーディング：脳-身体連関を規定するグリア情報の読み出しと理解 |
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| 研究課題/領域番号 |
23H04148
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| 研究機関 | 筑波大学 |
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研究代表者 |
ラザルス ミハエル 筑波大学, 国際統合睡眠医科学研究機構, 教授 (80469650)
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| 研究期間 (年度) |
2023-04-01 – 2025-03-31
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| キーワード | sleep / glia |
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| 研究実績の概要 |
We successfully demonstrated sleep induction in the NAc of freely behaving mice by increasing the activity of extracellular adenosine derived from astrocytes and neurons with a photoactivatable allosteric modulator of adenosine A2A receptors. We also showed that cytokine production in microglia during wakefulness is important for maintaining wakefulness, demonstrating the importance of glia-mediated neuroimmune interactions in the sleep-wake cycle.
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| 現在までの達成度 |
現在までの達成度
2: おおむね順調に進展している
理由
The paper, "Optochemical control of slow-wave sleep in the nucleus accumbens of male mice by a photoactivatable allosteric modulator of adenosine A2A receptors," has been published in the high-impact journal Nature Communications.
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| 今後の研究の推進方策 |
We continue to perform biochemical and genetic experiments to analyze the function of inflammation-related genes in the NAc. These analyses may help to unravel microglia-neuron interactions in sleep/wake regulation, provide new insights into the link between sleep homeostasis and immune resilience, and identify potential therapeutic targets for the treatment of sleep disorders.
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