Lipid Mediators and Lipid Metaborome

• Project/Area Number: 15002004
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: SHIMIZU Takao 東大, 医学(系)研究科(研究院), 教授 (80127092)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Motonao The University of Tokyo, Graduate School of Medicine, Associate Professor (40431762) ; SHINDOU Hideo The university of Tokyo, Graduate School of Medicine, Reseawrch Assistant (10401027) ; KITA Yoshihiro The University of Tokyo, Graduate School of Medicine, Research Assistant (20401028) ; TAKAHASHI Toshie The University of Tokyo, Graduate School of Medicine, Research Assistant (80236299) ; 田口 良 東京大学, 大学院・医学系研究科, 寄附講座教員(客員教授) (20080210) ; 奥野 利明 東京大学, 大学院・医学系研究科, 寄附講座教員(助手相当) (60361466) ; 魚住 尚紀 東京大学, 大学院・医学系研究科, 助手 (70313096) ; 谷口 雅彦 東京大学, 大学院・医学系研究科, 助手 (70260346) ; 石井 聡 東京大学, 大学院・医学系研究科, 助手 (10300815) ; 横溝 岳彦 東京大学, 大学院・医学系研究科, 助教授 (60302840)
• Project Period (FY): 2003 – 2006
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥692,900,000 (Direct Cost: ¥533,000,000、Indirect Cost: ¥159,900,000); Fiscal Year 2007: ¥119,600,000 (Direct Cost: ¥92,000,000、Indirect Cost: ¥27,600,000); Fiscal Year 2006: ¥119,600,000 (Direct Cost: ¥92,000,000、Indirect Cost: ¥27,600,000); Fiscal Year 2005: ¥131,300,000 (Direct Cost: ¥101,000,000、Indirect Cost: ¥30,300,000); Fiscal Year 2004: ¥136,500,000 (Direct Cost: ¥105,000,000、Indirect Cost: ¥31,500,000); Fiscal Year 2003: ¥185,900,000 (Direct Cost: ¥143,000,000、Indirect Cost: ¥42,900,000)
• Keywords: Lipid mediator / Acyltransferase / Platelet-activating factor / Phospholipase A2 / G protein-coupled receptor / Knockout mice (or Gene-deficient mice) / Metabolome / Pulmonary surfactant lipids / アシル転位酵素 / ロイトコイエン / 質量分析計 / ロイトコリエン / Gタンパク共役型受容 / ロイコトリエン

Research Abstract

1 Functional analysis of lysophospholipid acyltransferase ; We identified several lysophospholipid acyltransferases involving in the remodeling pathway of membrane lipids biosynthesis by in silico database analyses. Based on these information, we succeeded in molecular cloning of lyso-PAF acetyltransferase and LPCAT1. Lyso-PAF acetyltransferase is a critical enzyme in stimulus dependent formation of PAR LPCAT1 is an acetyltransferase involving in synthesis of phosphatidylcholine in pulmonary surfactant and play a pivotal role in respiratory physiology. We are generating gene-deficient mice of these enzymes to clarify the physiological importance. We further analyze other enzymes in this family.
2 Functional analysis of phospholipase A_2 (PLA_2) ; Among many mammalian PLA_2s, cytosolic PLA_2 α(cPLA_2α) plays a critical role in various physiological and pathophysiological conditions through generating lipid mediators. We newly discovered cPLA_2 family enzymes, cPLA_2δ, cPLA_2ε, and cPLA_2 ζ . We are analyzing the physiological function of these enzymes.
3 Identification of novel lipid mediator receptors (G-protein coupled receptors : GPCRs) ; To search for novel lipid mediator receptors among approx. 150 orphan GPCRs, we succeeded in selecting approx. 30 candidate GPCRs. In these GPCRs, we have newly identified TDAG8 and G2A as proton-sensing receptors and LPA4 as a lysophosphatidic acid receptor. We are continuously performing the ligand screening for other orphan GPCRs.
4 Analysisi of GPCR-deficient mice ; To clarify the physiological significance of lipid mediator GPCRs, we have generated genedeficient mice for BLT1, BLT2, CysLT2 and LPA4. In the analysis of BLT1-deficient mice, we obtained evidence that BLT1 is necessary for production of Th2 cytokines and the development of airway hyperresponsiveness in an OVA-induced bronchial asthma model.
5 High throughput quantitation of lipid mediators by LC-MS ; By the combination of lipid chromatography and tandem mass spectrometry (MS/MS), we developed a highly specific and reasonably sensitive assay procedure to simultaneously quantitate > 14 different mediators in 10 min single run.

Research Products

• [Journal Article] Immunomodulation by n-3- vs. n-6-rich lipid emulsions in munne acute lung injury ? role of platelet-activating factor receptor. (2007)
  • Author(s): Schaefer, M. B., Ott, J., Mohr, A., Bi, M. H., Grosz, A., Weissmann, N., Ishii, S., Grimminger, F., Seeger, W., Mayer, K.
  • Journal Title: Crit. Care Med. 35 Pages: 544-554
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Identification of the lntracellular region of the Leukotriene B4 receptor type-1 tnat specifically involves in Gi-activation. (2007)
  • Author(s): Kuniyeda, K., Okuno, T., Terawaki, K., Miyano, M., Yokomizo, T., Shimizu, T.
  • Journal Title: J. Biol. Chem. 282 Pages: 3998-4006
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] LPA4/p2y9/GPR23 mediates Rho-dependent morphological changes in a rat neuronal cell line. (2007)
  • Author(s): Yanagida. K., Ishii, S., Hamano, F., Noguchi, K., Shimizu, T.
  • Journal Title: J. Biol. Chem. 282 Pages: 5814-5824
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A single enzyme catalyzes both PAF production and membrane biogenesis of inflammatory cells : cloning and characterization of acetyl-CoA : lyso-PAF acetyltransferase. (2007)
  • Author(s): Shindou, H., Hishikawa, D., Nakanishi, H., Harayama, T., Ishii, S., Taguchi, R., Shimizu, T.
  • Journal Title: J. Biol. Chem. 282 Pages: 6532-6539
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Immunomodulation by n-3- vs. n-6-rich lipid emulsions in murine acute lung injury - role of platelet-activating factor receptor. (2007)
  • Author(s): Schaefer, M. B., Ott, J., Mohr, A., Bi, M. H., Grosz, A., Weissmann, N., Ishii, S., Grimminger, F., Seeger, W., Mayer, K.
  • Journal Title: Crit. Med. Care 35 Pages: 544-554
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification of the intracellular region of the Leukotriene B4 receptor type-1 that specifically involves in Gi-activation. (2007)
  • Author(s): Kuniyeda, K., Okuno, T., Terawaki, K., Miyano, M., Yokomizo, T., Shimizu, T.
  • Journal Title: J. Biol. Chem. 282 Pages: 3998-4006
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] LPA4/p2y9/GPR23 mediates Rho-dependent morphological changes in a rat neuronal cell line. (2007)
  • Author(s): Yanagida, K., Ishii, S., Hamano, F., Noguchi, K., Shimizu, T.
  • Journal Title: J. Biol. Chem. 282 Pages: 5814-5824
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Immunomodulation by n-3- vs. n-6-rich lipid emulsions in murine acute lung injury-role of platelet-activating factor receptor. (2007)
  • Author(s): Schaefer, M.B., Ott, J., Mohr, A., Bi, M.H., Grosz, A., Weissmann, N., Ishii, S., Grimminger, F., Seeger, W., Mayer, K.
  • Journal Title: Crit. Care Med. 35 Pages: 544-554
• [Journal Article] Involvement of the platelet activating factor receptor in host defence against Streptococcus pneumoniae during post influenza pneumonia. (2006)
  • Author(s): van der Sluijs, K. F., van El den. L. J. R., Nijhuis, M., Schuurman, R., lorquin, S., Shimizu, T., Ishii, S., Jansen, H. M., Lutter, R., van der Poll, T.
  • Journal Title: Am. J. Physiol. 290
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Attenuation of folic acid-induced renal inflammatory injury in platelet-activating factor receptor-deficient mice. (2006)
  • Author(s): Doi, K., Okamoto, K., Negishi, K., Suzuki, Y., Nakao, A., Fujita, T., Toda, A., Yokomizo, T., Kita, Y., Kihara, Y., Ishii, S., Shimizu, T., Noiri, E.
  • Journal Title: Am. J. Pathol. 168 Pages: 1413-1424
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Profiling of eicosanoid production in the rat hippocampus during kainate-induced seizure : Dual-phase regulation and differential involvement of cox-1 and cox-2. (2006)
  • Author(s): Yoshikawa, K., Kita, Y., Kishimoto, K., Shimizu, T.
  • Journal Title: J. Biol. Chem. 281 Pages: 14663-14669
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cloning and characterization of mouse lung-type acyl-coa : lysophosphatidy1choline acyltransferase 1 (LPCATl) : Expression in alveolar type II cells, and possible involvement in surfactant production. (2006)
  • Author(s): Nakanishi, H., Shindou, H., Hishikawa, D., Harayama, T., Ogasawara, R., Suwabe, A., Taguchi, R., Shimizu, T.
  • Journal Title: J. Biol. Chem. 281 Pages: 20140-20147
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Sensory system-predominant distribution of leukotriene a(4) hydrolase and Its colocalization with calretinin in the mouse nervous system. (2006)
  • Author(s): Chiba, Y., Shimada, A., Satoh, M., Saitoh, Y., Kawamura, N., Hanai, A., Keino, H., Ide, Y., Shimizu, T., Hosokawa, M.
  • Journal Title: Neurosci. 141 Pages: 917-927
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cytosolic phospholipase A2 : Biochemical properties and physiological roles. (2006)
  • Author(s): Shimizu, T., Ohto, T., Kita, Y.
  • Journal Title: IUBMB Life 58 Pages: 328-333
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Group IVA phospholipase A(2)-mediated production of fibronectin by oxidized LDL in mesangial cells. (2006)
  • Author(s): Akiba, S., Mukaida, Y., Hane, K., Oka, M., Uozumi, N., Shimizu, T., Sato, T.
  • Journal Title: Kidney Int. 70 Pages: 1013-1018
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Biochemical properties and pathophysiological roles of cytosolic phospholipase A2s. (2006)
  • Author(s): Kita, Y., Ohto, T., Uozumi, N., Shimizu, T.
  • Journal Title: Biochim. Biophys. Acta 1761 Pages: 1317-1322
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Involvement of the platelet activating factor receptor in host defence against Streptococcus pneumoniae during postinfluenza pneumonia. (2006)
  • Author(s): van der Sluijs, K. F., van Elden, L. J. R., Nijhuis, M., Schuurman, R., lorquin, S., Shimizu, T., Ishii, S., Jansen, H. M., Lutter, R., van der Poll, T.
  • Journal Title: Am. J. Physiol. 290
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Attenuation of folic acid-induced renal inflammatory injury in platelet-activating factor receptor-deficient mice. (2006)
  • Author(s): Doi, K., Okamoto, K., Negishi, K., Suzuki, Y., Nakao, A., Fujita, T., Toda, A., Yokomizo, T., Kita, Y., Kihara, Y., Ishii, S., Shimizu, T., Noiri, E
  • Journal Title: Am. J. Pathol. 168 Pages: 1413-1424
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cloning and characterization of mouse lung-type acyl-coa : lysophosphatidylcholine acyltransferase 1 (LPCAT1) : Expression in alveolar type II cells, and possible involvement in surfactant production. (2006)
  • Author(s): Nakanishi, H., Shindou, H., Hishikawa, D., Harayama, T., Ogasawara, R., Suwabe, A., Taguchi, R., Shimizu, T.
  • Journal Title: J. Biol. Chem. 281 Pages: 20140-20147
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Sensory system-predominant distribution of leukotriene a(4) hydrolase and its colocalization with calretinin in the mouse nervous system. (2006)
  • Author(s): Chiba, Y., Shimada, A., Satoh, M., Saitoh, Y., Kawamura, N., Hanai, A., Keino, H., Ide, Y., Shimizu, T., Hosokawa, M.
  • Journal Title: Neurosci. 141 Pages: 917-927
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Group IVA phospholipase A(2)-mediated production of fibronectin by oxidized LDL in mesangial cells. (2006)
  • Author(s): Akiba, S., Mukaida, Y., Hane, K., Oka, M., Uozumi, N., Shimizu, T., Sato, T.
  • Journal Title: Kidney Int 70 Pages: 1013-1018
• [Journal Article] Involvement of the platelet activating factor receptor in host defense against Streptococcus pneumoniae during postinfluenza pneumonia. (2006)
  • Author(s): van der Sluijs, K.F., van Elden, L.J.R., Nijhuis, M., Schuurman, R., lorquin, S., Shimizu, T., Ishii, S., Jansen, H.M., Lutter, R., van der Poll, T.
  • Journal Title: Am. J. Physiol. 290
• [Journal Article] Identification of T cell death-associated gene 8 (TDAG8) as a novel acid sensing G-protein-coupled receptor. (2005)
  • Author(s): Ishii, S., Kihara, Y., Shimizu, T.
  • Journal Title: J. Biol. Chem. 280 Pages: 9083-9087
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Stimulation of erythrocyte ceramide formation by platelet activating factor. (2005)
  • Author(s): Lang, P. A., Kempe, D. S., Tanneur, V., Eisele, K., Klarl, B. A., Myssina, S., Jendrossek, V., Ishii, S., Shimizu, T., Waidmann, M., Hessler, G., Huber, S. M., Lang, F., Wieder, T.
  • Journal Title: J. Cell Sci. 118 Pages: 1233-1243
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A shotgun tandem mass spectrometric analysis of hospholipids with normal-phase and/or reverse-phase liquid chromtography/electrospray ionization mass spectrometry. (2005)
  • Author(s): Houjou, T., Yamatani, K., Imagawa, M, Shimizu, T., Taguchi, R.
  • Journal Title: Rapid Commun. Mass Spectrom. 19 Pages: 654-666
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Highly selective localization of leukotriene C4 synthase in hypothalamic and extrahypothalamic vasopressin systems of mouse brain. (2005)
  • Author(s): Shimada, A., Satoh, M., Chiba, Y., Saitoh, Y., Kawamura, N., Keino, H., Hosokawa, M., Shimizu T.
  • Journal Title: Neurosci. 131 Pages: 683-689
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Pathway-orient ed profiling of lipid mediators in macrophages. (2005)
  • Author(s): Kita, Y., Takahashi, T. . Uozumi, N., Nallan, L., Gelb, M. H., Shimizu, T
  • Journal Title: Biochem. Biophys. Res. Commun. 330 Pages: 898-906
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Specific detection oflysphosphatidic acids in serum extracts by tandem mass spectrometry. (2005)
  • Author(s): Ishida, M., Imagawa, M. . Shimizu, T., Taguchi, R.
  • Journal Title: J. Mass Spectrom. Soc. Jpn. 53 Pages: 25-32
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A multiplex quantitation method for eicosanoids and platelet-activating factor using column-switching reversed-phase liquid chromatography-tandem mass spectrometry・ (2005)
  • Author(s): Kita, Y., Takahashi, T., Uozumi, N., Shimizu, T.
  • Journal Title: Anal. Biochem. 342 Pages: 134-143
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Identification and characterization of a novel member of murine semaphorin family. (2005)
  • Author(s): Taniguchi, M., Masuda, T., Fukaya, M. . Kataoka, H., Mishina, M., Yaginuma, H., Watanabe, M., Shimizu, T.
  • Journal Title: Genes to Cells 10 Pages: 785-792
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Characterization of a mouse second leukotriene B4 receptor. mBLT2. (2005)
  • Author(s): Iizuka, Y., Yokomizo, T., Terawaki, K., Komine, M., Tamaki. K., Shimizu T.
  • Journal Title: J. Biol. Chem. 280 Pages: 24816-24823
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Identification of novel cytosolic phospholipase A2s. murine cPLA2 delta, epsilon, and zeta, which form a gene cluster with cPLA2 beta. (2005)
  • Author(s): Ohto, T., Uozumi, N., Hirabayashi, T., Shimizu, T.
  • Journal Title: J. Biol. Chem. 280 Pages: 24576-24583
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Priming effect of 1 ipopo1ysaccharide on acetyl-CoA : lyso-PAF acetyltransferase IS MyD88 and TRIF-independent. (2005)
  • Author(s): Shindou, H., Ishii, S., Yamamoto, M., Takeda, K., Akira, S., Shimizu, T
  • Journal Title: J. Immunol. 175 Pages: 1177-1183
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Group X secretory phospholipase A2 can induce arachidonic acid release and eicosanoidproduction without activation of cytosolic phospholipase A2. (2005)
  • Author(s): Saiga, A. . Uozumi, N., Ono, T., Seno, K., Ishimoto, Y., Arita, H., Shimizu, T. ., Hanasaki. K.
  • Journal Title: Prostaglandins Other Lipid Med. 75 Pages: 79-89
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A comprehensive classification system for lipids. (2005)
  • Author(s): Fahy, E., Subramaniam, S., Brown, A., Glass, C. K., Merrill, A. H., Jr., Murphy, R. C., Raetz, E. R. H., Russell. D. W., Seyama, Y., Shaw, W., Shimizu, T., Spener, F., van Meer, G., VanNieuwenhze, M. S., Stephen H. White, S. H., Witztum. J. L., Dennis, E. A.
  • Journal Title: J. Lipid Res. 46 Pages: 839-862
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Synthesis of 2-, 4- and 5-(2-alkylcarbamoyl-l-methylvinyl)-7-alkyloxybenzo[b]furans and their leukotriene B(4)receptor antagonistic activity. (2005)
  • Author(s): Ando, K., Tsuji, E., Ando, Y., Kunitomo, J., Kobayashi, R., Yokomizo, T., Shimizu, T., Yamashita, M., Ohta, S., Nabe, T., Kohno. S., Ohishi, Y.
  • Journal Title: Org. Biomol. Chem. 3 Pages: 2129-2139
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity reactions via the platelet-activating factor receptor. (2005)
  • Author(s): Zhang, Q., Mousdicas, N., Yi, Q., Al-Hassani. M., Billings, S. D., Perkins, S. M., Howard. K. M. . Ishii. S., Shimizu, T., Travers, J. B.
  • Journal Title: J. Clin. Invest. 115 Pages: 2855-2861
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Absence of leukotriene B4 receptor l confers resistance to airway hyperresponsivenessand Th2 type immune responses. (2005)
  • Author(s): Terawaki, K., Yokomizo, T., Nagase, T., Toda, A., Taniguchi, M., Hashizume, K., Yagi, T., Shimizu, T.
  • Journal Title: J. Immunol. 175 Pages: 4217-4225
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Leukotriene B4 receptor and the function of its helix 8. (2005)
  • Author(s): Okuno, T., Yokomizo, T., Hori, T., Miyano, M., Shimizu, T.
  • Journal Title: J. Biol. Chem. 280 Pages: 32049-32052
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor. (2005)
  • Author(s): Kihara, Y., Ishii, S., Kita. Y., Toda, A., Shimada, A., Shimizu, T
  • Journal Title: J. Exp. Med. 202 Pages: 853-863
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cytosolic phospholipase A2alpha-deficient mice are resistant to experimental autoimmune encephalomyelitis. (2005)
  • Author(s): Marusic, S., Leach, M, W, Pelker, J. w., Azoitei, M. L., Uozumi, N., Cui, J., DeClercq, CM., Shen, M. W. H., Miyashiro, J. S., Carito, B. A., Thakker, P., Simmons, D. L., Leonard, J. P., Shimizu, T., Clark, J. D.
  • Journal Title: J. Exp. Med. 202 Pages: 841-851
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Protective role for cytosolic phospholipase A2alpha in autoimmune diabetes of mice. (2005)
  • Author(s): Oikawa, Y., Yamato, E., Tashiro, F., Yamamoto, M., Uozumi, N., Shimada, A., Shimizu T. ., Miyazaki, J.
  • Journal Title: FEBS Lett. 579 Pages: 3975-3978
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Recruitment of katanin p60 by phosphorylated NDELl, a LISl interacting protein, is essential for mitotic cell division and neuronal migration. (2005)
  • Author(s): Toyo-oka, K., Sasaki, S., Yano, Y., Mori, D., Kobayashi, T., Toyoshima, y. Y., Tokuoka, S. M., Ishii, S., Shimizu, T., Muramatsu, M., Hiraiwa, N., Yoshiki, A., Wynshaw-Boris, A., Hirotsune, S.
  • Journal Title: Hum. Mol. Genet. 14 Pages: 3113-3128
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A shotgun tandem mass spectrometric analysis of hospholipids with normal-phase and/or reverse-phase liquid chromtography/electrospray ionization mass spectrometry. (2005)
  • Author(s): Houjou, T., Yamatani, K., Imagawa, M, Shimizu, T., Taguchi, R.
  • Journal Title: Rapid Commun. Mass Spectrom 19 Pages: 654-666
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Highly selective localization of leukotriene C4 synthase in hypothalamic and extrahypothalamic vasopressin systems of mouse brain. (2005)
  • Author(s): Shimada, A., Satoh, M., Chiba, Y., Saitoh, Y., Kawamura, N., Keino, H., Hosokawa, M., Shimizu, T.
  • Journal Title: Neurosci. 131 Pages: 683-689
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pathway-oriented profiling of lipid mediators in macrophages. (2005)
  • Author(s): Kita, Y., Takahashi, T., Uozumi, N., Nallan, L., Gelb, M. H., Shimizu, T.
  • Journal Title: Biochem. Biophys. Res. Commun. 330 Pages: 898-906
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Specific detection oflysphosphatidic acids in serum extracts by tandem mass spectrometry. (2005)
  • Author(s): Ishida, M., Imagawa, M., Shimizu, T., Taguchi, R.
  • Journal Title: J. Mass Spectrom. Soc. Jpn. 53 Pages: 25-32
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A multiplex quantitation method for eicosanoids and platelet-activating factor using column-switching reversed-phase liquid chromatography-tandem mass spectrometry. (2005)
  • Author(s): Kita, Y., Takahashi, T., Uozumi, N., Shimizu, T.
  • Journal Title: Anal. Biochem. 342 Pages: 134-143
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification and characterization of a novel member of murine semaphorin family. (2005)
  • Author(s): Taniguchi, M., Masuda, T., Fukaya, M., Kataoka, H., Mishina, M., Yaginuma, H., Watanabe, M., Shimizu, T.
  • Journal Title: Genes to Cells 10 Pages: 785-792
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Characterization of a mouse second leukotriene B4 receptor, mBLT2. (2005)
  • Author(s): Iizuka, Y., Yokomizo, T., Terawaki, K., Komine, M., Tamaki, K., Shimizu, T.
  • Journal Title: J. Biol. Chem. 280 Pages: 24816-24823
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification of novel cytosolic phospholipase A2s, murine cPLA2 delta, epsilon, and zeta, which form a gene cluster with cPLA2 beta. (2005)
  • Author(s): Ohto, T., Uozumi, N., Hirabayashi, T., Shimizu, T.
  • Journal Title: J. Biol. Chem. 280 Pages: 24576-24583
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Priming effect of lipopolysaccharide on acetyl-CoA : lyso-PAF acetyltransferase is MyD88 and TRIP-independent. (2005)
  • Author(s): Shindou, H., Ishii, S., Yamamoto, M., Takeda, K., Akira, S., Shimizu, T.
  • Journal Title: J. Immunol. 175 Pages: 1177-1183
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Group X secretory phospholipase A2 can induce arachidonic acid release and eicosanoid production without activation of cytosolic phospholipase A2. (2005)
  • Author(s): Saiga, A., Uozumi, N., Ono, T., Seno, K., Ishimoto, Y., Arita, H., Shimizu, T., Hanasaki, K.
  • Journal Title: Prostaglandins Other Lipid Med. 75 Pages: 79-89
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A comprehensive classification system for lipids. (2005)
  • Author(s): Fahy, E., Subramaniam, S., Brown, A., Glass, C. K., Merrill, A. H., Jr., Murphy, R. C., Raetz, E. R. H., Russell, D. W., Seyama, Y., Shaw, W., Shimizu, T., Spener, F., van Meer, G., VanNieuwenhze, M. S., Stephen H. White, S. H., Witztum, J. L., Dennis, E. A.
  • Journal Title: J. Lipid Res. 46 Pages: 839-862
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Synthesis of 2-, 4- and 5-(2-alkylcarbamoyl-1-methylvinyl)-7-alkyloxybenzo[b]furans and their leukotriene B(4) receptor antagonistic activity. (2005)
  • Author(s): Ando, K., Tsuji, E., Ando, Y., Kunitomo, J., Kobayashi, R., Yokomizo, T., Shimizu, T., Yamashita, M., Ohta, S., Nabe, T., Kohno, S., Ohishi, Y.
  • Journal Title: Org. Biomol Chem. 3 Pages: 2129-2139
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity reactions via the platelet-activating factor receptor. (2005)
  • Author(s): Zhang, Q., Mousdicas, N., Yi, Q., Al-Hassani, M., Billings, S. D., Perkins, S. M., Howard, K. M., Ishii, S., Shimizu, T., Travers, J. B.
  • Journal Title: J. Clin Invest. 115 Pages: 2855-2861
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Absence of leukotriene B4 receptor 1 confers resistance to airway hyperresponsiveness and Th2 type immune responses. (2005)
  • Author(s): Terawaki, K., Yokomizo, T., Nagase, T., Toda, A., Taniguchi, M., Hashizume, K., Yagi, T., Shimizu, T.
  • Journal Title: J. Immunol. 175 Pages: 4217-4225
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor. (2005)
  • Author(s): Kihara, Y., Ishii, S., Kita, Y., Toda, A., Shimada, A., Shimizu, T.
  • Journal Title: J. Exp. Med. 202 Pages: 853-863
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cytosolic phospholipase A2alpha-deficient mice are resistant to experimental autoimmune encephalomyelitis. (2005)
  • Author(s): Marusic, S., Leach, M. W., Pelker, J. W., Azoitei, M. L., Uozumi, N., Cui, J., DeClercq, C. M., Shen, M. W. H., Miyashiro, J. S., Carito, B. A., Thakker, P., Simmons, D. L., Leonard, J. P., Shimizu, T., Clark, J. D.
  • Journal Title: J. Exp. Med. 202 Pages: 841-851
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Protective role for cytosolic phospholipase A2alpha in autoimmune diabetes of mice. (2005)
  • Author(s): Oikawa, Y., Yamato, E., Tashiro, F., Yamamoto, M., Uozumi, N., Shimada, A., Shimizu, T., Miyazaki, J.
  • Journal Title: FEBS Lett. 579 Pages: 3975-3978
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Recruitment of katanin p60 by phosphorylated NDEL1, a LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. (2005)
  • Author(s): Toyo-oka, K., Sasaki, S., Yano, Y., Mori, D., Kobayashi, T., Toyoshima, Y. Y., Tokuoka, S. M., Ishii, S., Shimizu, T., Muramatsu, M., Hiraiwa, N., Yoshiki, A., Wynshaw-Boris, A., Hirotsune, S.
  • Journal Title: Hum. Mol. Genet. 14 Pages: 3113-3128
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Recruitment of katanin p60 by phosphorylated NDEL1, a LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. (2005)
  • Author(s): Toyo-oka, K., Sasaki, S., Yano, Y., Mori, D., Kobayashi, T., Toyoshima, Y.Y., Tokuoka, S.M., Ishii, S., Shimizu, T., Muramatsu, M., Hiraiwa, N., Yoshiki, A., Wynshaw-Boris, A., Hirotsune, S.
  • Journal Title: Human Molecular Genetics 14 Pages: 3113-3128
• [Journal Article] Protective role for cytosolic phospholipase A2alpha in autoimmune diabetes of mice. (2005)
  • Author(s): Oikawa, Y., Yamato, E., Tashiro, F., Yamamoto, M., Uozumi, N., Shimada, A., Shimizu, T., Miyazaki, J.
  • Journal Title: FEBS Letter. 579 Pages: 3975-3978
• [Journal Article] Cytosolic phospholipase A2a-deficient mice are resistant to experimental autoimmune encephalomyelitis (2005)
  • Author(s): Marusic, S., Leach, M.W., Pelker, J.W., Azoitei, M.L., Uozumi, N., Cui, J., DeClercq, C.M., Shen, M.W.H., Miyashiro, J.S., Carito, B.A., Thakker, P., Simmons, D.L., Leonard, J.P., Shimizu, T., Clark, J.D.
  • Journal Title: Journal of Experimental Medicine 202 Pages: 841-851
• [Journal Article] Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor (2005)
  • Author(s): Kihara, Y., Ishii, S., Kita, Y., Toda, A., Shimada, A., Shimizu, T.
  • Journal Title: Journal of Experimental Medicine 202 Pages: 853-863
• [Journal Article] Leukotriene B4 receptor and the function of its helix 8 (2005)
  • Author(s): Okuno, T., Yokomizo, T., Hori, T., Miyano, M., Shimizu, T.
  • Journal Title: Journal of Biological Chemistry 280 Pages: 32049-32052
• [Journal Article] Absence of leukotriene B4 receptor 1 confers resistance to airway hyperresponsiveness and Th2 type immune responses (2005)
  • Author(s): Terawaki, K., Yokomizo, T., Nagase, T., Toda, A., Taniguchi, M., Hashizume, K., Yagi, T., Shimizu, T.
  • Journal Title: Journal of Immunology 175 Pages: 4217-7225
• [Journal Article] Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity reactions via the platelet-activating factor receptor. (2005)
  • Author(s): Zhang, Q., Mousdicas, N., Yi, Q., Al-Hassani, M., Billings, S.D., Perkins, S.M., Howard, K.M., Ishii, S., Shimizu, T., Travers, J.B.
  • Journal Title: Journal of Clinical Investigation 115 Pages: 2855-2861
• [Journal Article] Synthesis of 2-, 4- and 5-(2-alkylcarbamoyl-1-methylvinyl)-7-alkyloxybenzo[b]furans and their leukotriene B(4) receptor antagonistic activity. (2005)
  • Author(s): Ando, K., Tsuji, E., Ando, Y., Kunitomo, J., Kobayashi, R., Yokomizo, T., Shimizu, T., Yamashita, M., Ohta, S., Nabe, T., Kohno, S., Ohishi, Y.
  • Journal Title: Organic Biomolecular Chemistry 3 Pages: 2129-2139
• [Journal Article] A comprehensive classification system for lipids. (2005)
  • Author(s): Fahy, E., Subramaniam, S., Brown, A., Glass, C.K., Merrill, A.H.Jr., Murphy, R.C., Raetz, E.R.H., Russell, D.W., Seyama, Y., Shaw, W., Shimizu, T., Spener, F., van Meer, G., VanNieuwenhze, M.S., Stephen H., White, S.H., Witztum, J.L., Dennis, E.A.
  • Journal Title: Journal of Lipid Research 46 Pages: 839-862
• [Journal Article] Group X secretory phospholipase A2 can induce arachidonic acid release and eicosanoid production without activation of cytosolic, phospholipase A2. (2005)
  • Author(s): Saiga, A., Uozumi, N., Ono, T., Seno, K., Ishimoto, Y., Arita, H., Shimizu, T., Hanasaki, K.
  • Journal Title: Prostaglandins and Other Lipid Mediators 46 Pages: 839-862
• [Journal Article] Priming effect of lipopolysaccharide on acetylCoA lysoPAF acetyltransferase. (2005)
  • Author(s): Shindou, H., Ishii, S., Yamamoto, M., Takeda, K., Akira, S., Shimizu, T.
  • Journal Title: Journal of Immunology 175 Pages: 1177-1183
• [Journal Article] Identification of novel cytosolic phospholipase A2s, murine cPLA2 delta, epsilon, and zeta, which form a gene cluster with cPLA2 beta. (2005)
  • Author(s): Ohto, T., Uozumi, N., Hirabayashi, T., Shimizu, T.
  • Journal Title: Journal of Biological Chemistry 280 Pages: 24576-24583
• [Journal Article] Characterization of a mouse second leukotriene B4 receptor, mBLT2. (2005)
  • Author(s): Iizuka, Y., Yokomizo, T., Terawaki, K., Komine, M., Tamaki, K., Shimizu, T.
  • Journal Title: Journal of Biological Chemistry 280 Pages: 24816-24823
• [Journal Article] A multiplex quantitation method for eicosanoids and platelet-activating factor using column-switching reversed-phase liquid chromatography-tandem mass spectrometry. (2005)
  • Author(s): Kita, Y., Takahashi, T., Uozumi, N., Shimizu, T.
  • Journal Title: Analytical Biochemistry 342 Pages: 134-143
• [Journal Article] Specific detection oflysphosphatidic acids in serum extracts by tandem mass spectrometry. (2005)
  • Author(s): Ishida, M., Imagawa, M., Shimizu, T., Taguchi, R.
  • Journal Title: Journal of the Mass Spectrometry Society of Japan 53 Pages: 25-32
• [Journal Article] Pathway-oriented profiling of lipid mediators in macrophages. (2005)
  • Author(s): Kita, Y., Takahashi, T., Uozumi, N., Nallan, L., Gelb, M.H., Shimizu, T.
  • Journal Title: Biochemical and Biophysical Research Communications 330 Pages: 898-906
• [Journal Article] Highly selective localization of leukotriene C4 synthase in hypothalamic and extrahypothalamic vasopressin systems of mouse brain. (2005)
  • Author(s): Shimada, A., Satoh, M., Chiba, Y., Saitoh, Y., Kawamura, N., Keino, H., Hosokawa, M., Shimizu, T.
  • Journal Title: Neuroscience 131 Pages: 683-689
• [Journal Article] A shotgun tandem mass spectrometric analysis of hospholipids with normal-phase and/or reverse-phase liquid chromtography/electrospray ionization mass spectrometry. (2005)
  • Author(s): Houjou, T., Yamatani, K., Imagawa, M, Shimizu, T., Taguchi, R.
  • Journal Title: Rapid Communications in Mass Spectrometry 19 Pages: 654-666
• [Journal Article] Stimulation of erythrocyte ceramide formation by platelet activating factor. (2005)
  • Author(s): Lang, P.A., Kempe, D.S., Tanneur, V., Eisele, K., Klarl, B.A., Myssina, S., Jendrossek, V., Ishii, S., Shimizu, T., Waidmann, M., Hessler, G., Huber, S.M., Lang, F., Wieder, T.
  • Journal Title: Journal of Cell Sciences 118 Pages: 1233-1243
• [Journal Article] Identification of T cell death-associated gene 8 (TDAG8) as a novel acid sensing G-protein-coupled receptor. (2005)
  • Author(s): Ishii, S., Kihara, Y., Shimizu, T.
  • Journal Title: Journal of Biological Chemistry 280 Pages: 9083-9087
• [Journal Article] Identification of T cell deathassociated gene 8(TDAG8) as a novel acid sensing G-protein-oupled receptor. (2005)
  • Author(s): Ishii, S. et al.
  • Journal Title: J.Biol.Chem. (in press)
• [Journal Article] structural basis of leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase catalytic mechanism and a possible SH3 binding loop. (2004)
  • Author(s): Hori, T., Yokomizo, T., Ago, H., Sugahara, M., Ueno, G., Yamamoto, M., Kumasaka T Shimizu T, Mivano
  • Journal Title: J. Biol. Chem. 279 Pages: 22615-22623
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Platelet-activating factor receptor develops airway hyperresponsiveness independently of airway inflammation in a murine asthma model. (2004)
  • Author(s): Ishii, S., Nagase, T., Shindou, H., Takizawa, H., Ouchi, Y., Shimizu, T.
  • Journal Title: J. Immunol. 172 Pages: 7095-7102
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Absence of platelet-activating factor receptor protects mice from osteoporosis following ovariectomy. (2004)
  • Author(s): Hikiji, H., Ishii, S., Shindou, H., Takato, T., Shimizu, T.
  • Journal Title: J. Clin. Invest. 114 Pages: 85-93
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] G2A is a proton-sensing G-protein coupled receptor antagonized by lysophosphatidylcholine. (2004)
  • Author(s): Murakami, N., Yokomizo, T., Okuno, T., Shimizu, T.
  • Journal Title: J. Biol. Chem. 279 Pages: 42484-42491
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Rapid and selective identification of molecular species in phosphatidylcholine and sphingomyelin by conditional neutral loss scanning and MS3. (2004)
  • Author(s): Houjou, T, Yamatani, K., Nakanishi, H., Imagawa, M., Shimizu, T., Taguchi R.
  • Journal Title: Rapid Commun. Mass Spectrom. 18 Pages: 3123-3130
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Structural basis of leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase catalytic mechanism and a possible SH3 binding loop. (2004)
  • Author(s): Hori, T., Yokomizo, T., Ago, H., Sugahara, M., Ueno, G., Yamamoto, M., Kumasaka, T., Shimizu, T. Miyano, M.
  • Journal Title: J. Biol. Chem. 279 Pages: 22615-22623
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Rapid and selective identification of molecular species in phosphatidylcholine and sphingomyelin by conditional neutral loss scanning and MS3. (2004)
  • Author(s): Houjou, T, Yamatani, K., Nakanishi, H., Imagawa, M., Shimizu, T., Taguchi, R.
  • Journal Title: Rapid Commun. Mass Spectrom. 18 Pages: 3123-3130
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] G2A is a a protonsensing G-protein coupled receptor antagonized by lysophosphatidylcholine. (2004)
  • Author(s): Murakami, N. et al.
  • Journal Title: J.Biol.Chem. 279 Pages: 42484-42491
• [Journal Article] Platelet-activating factor receptor develops airway hyperresponsiveness independently of airway inflammation in a marine asthma model. (2004)
  • Author(s): Ishii, S. et al.
  • Journal Title: J.Immunol. 172 Pages: 7095-7102
• [Journal Article] Absence of platelet-activating factor receptor protects mice from osteoporosis following ovariectomy. (2004)
  • Author(s): Hikiji, H. et al.
  • Journal Title: J.Clin.Invest. 114 Pages: 85-93
• [Journal Article] Rapid and selective identification of molecular species in phosphatidylcholine and sphingomyelin by conditional neutral los scanning and MS3. (2004)
  • Author(s): Houjou, T. et al.
  • Journal Title: Rapid Commun.Mass Spectrom. 18 Pages: 3123-3130
• [Journal Article] Structural basis of leukotriene B4 12-hydroxydehydrogenase/15-oxo-prosta-glandin 13-reductase catalytic mechanism and a possible SH3 binding loop. (2004)
  • Author(s): Hori, T. et al.
  • Journal Title: J.Biol.Chem. 279 Pages: 22615-22623
• [Journal Article] An Essential Role of Cytosolic Phospholipase A2 ・ in Prostaglandin E2-mediated Bone Resorption Associated with Inflammation (2003)
  • Author(s): Miyaura, C., Inada, M., Matsumoto, C., Ohshiba, C., Uozumi, N., Shimizu, T., Ito, A.
  • Journal Title: J. Exp. Med. 197 Pages: 1303-1310
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cytosolic Phospholipase A2 ・ deficient Mice Are Resistant to Collagen-induced Arthritis (2003)
  • Author(s): Hegen, M., Sun L., Uozumi N., Kume K., Goad, E. M., Nickerson-Nutter L. C., Shimizu T., Clark D. J.
  • Journal Title: J. Exp. Med. 197 Pages: 1297-1302
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Identification of p2y9/GPR23 as a Novel G Protein-Coupled Receptor for Lysophosphatidic Acid, Structurally Distant from the Edg Family (2003)
  • Author(s): Noguchi, K., Ishii, S., Shimizu, T.
  • Journal Title: J. Biol. Chem. 278 Pages: 25600-25606
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cloning of adiponectin receptors that mediate antidiabetic metabolic effects (2003)
  • Author(s): Yamauchi, T., Kamon, T., Ito, Y., Tsuchida, A., Yokomizo, T., Kta, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., Murakami, K., Ohteki T., Uchida, S., Takenawa, S., Waki H., Tsuno, N. H., Shibata, Y., Terauchi, Y., Froguel, P., Tobe, K., Koyasu, S., Taira, K., Kitamura, T., Shimizu, T., Nagai, R., Kadowaki, T.
  • Journal Title: Nature 423 Pages: 762-768
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Host response of platelet-activating factor receptor-deficient mice during pulmonary tuberculosis (2003)
  • Author(s): Weijer, S., Leemans, J. C., Florquin, S., Shimizu, T., Ishii, S., van der Poll. T.
  • Journal Title: Immunology 109 Pages: 552-556
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Helix 8 of the leukotriene B4 receptor is required for the conformational change to the low-affinity state after G-protein activation. (2003)
  • Author(s): Okuno, T., Ago, H., Terawaki., K, Miyano, M., Shimizu, T., Yokomizo T.
  • Journal Title: J. Biol. Chem. 278 Pages: 41500-41509
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] B-Myb-dependent regulation of c-Myc expression by cytosolic phospholipase A2. (2003)
  • Author(s): Tashiro, S., Sumi, T., Uozumi, N., Shimizu, T., Nakamura, T.
  • Journal Title: J. Biol. Chem. 279 Pages: 17715-17722
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cytosolic Phospholipase A2 ・ deficient Mice Are Resistant to Collagen-induced Arthritis (2003)
  • Author(s): Hegen, M., Sun L., Uozumi N., Kume K., Goad, E. M., Nickerson-Nutter L. C, Shimizu T., Clark D. J.
  • Journal Title: J. Exp. Med. 197 Pages: 1297-1302
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cloning of adiponectin receptors that mediate antidiabetic metabolic effects (2003)
  • Author(s): Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kta, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., Murakami, K., Ohteki T., Uchida, S., Takenawa, S., Waki H., Tsuno, N. H., Shibata, Y., Terauchi, Y., Froguel, P., Tobe, K., Koyasu, S., Taira, K., Kitamura, T., Shimizu, T., Nagai, R., Kadowaki, T.
  • Journal Title: Nature 423 Pages: 762-768
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Host response of platelet-activating factor receptor-deficient mice during pulmonary tuberculosis (2003)
  • Author(s): Weijer, S., Leemans, J. C., Florquin, S., Shimizu, T., Ishii, S., van der Poll, T.
  • Journal Title: Immunology 109 Pages: 552-556
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Helix 8 of the leukotriene B4 receptor is required for the conformational change to the low-affinity state after G-protein activation. (2003)
  • Author(s): Okuno, T., Ago, H., Terawaki., K, Miyano, M., Shimizu, T. Yokomizo T.
  • Journal Title: J. Biol. Chem. 278 Pages: 41500-41509
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Pathway-oriented profiling of lipid mediators. (Keynote speaker) (2006)
  • Author(s): 清水孝雄
  • Organizer: FASEB Summer Research Conference on Lysophospholipid Mediators
  • Place of Presentation: Tuscon, AZ.
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Lipid mediators ; fundamental regulators of immune responses and inflammatory reactions. (2006)
  • Author(s): 清水孝雄
  • Organizer: RCAI-JST (理研-日本免疫学会)International Symposium on Immunology
  • Place of Presentation: 横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The eicosanoid cascade : Lipid mediators of chronic inflammation. (2006)
  • Author(s): 清水孝雄
  • Organizer: Days of Molecular Medicine 2006 (organized by Karolinska Institute, MGH and Nature Medicine)
  • Place of Presentation: Stockholm
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Biochemistry and Biology of Leukotriene B4 receptors. (2006)
  • Author(s): 清水孝雄
  • Organizer: Keystone Symposia on Eicosanoido in Inoflammation and Chironic Diseases
  • Place of Presentation: Snowbird, Utah
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Comprehensive LC-MS analysis of lipid mediator generation. (2006)
  • Author(s): 北芳博
  • Organizer: FASEB Summer Research Conferences-Phospholiphases
  • Place of Presentation: Vermont, Saxson River
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Pathway-oriented profiling of lipidmediators. (Keynote speaker) (2006)
  • Author(s): Takao Shimizu
  • Organizer: FASEB Summer Research Conference on Lysophospholipid Mediators
  • Place of Presentation: Tuscon, AZ., USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Lipid mediators ; fundamental regulators of immune responses and inflammatory reactions. (2006)
  • Author(s): Takao Shimizu
  • Organizer: RCAI-JST International Symposium on Immunology
  • Place of Presentation: Yokohama, JAPAN
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The eicosanoid cascade : Lipid mediators of chronic inflammation. (2006)
  • Author(s): Takao Shimizu
  • Organizer: Days of Molecular Medicine 2006 (organized Karolinska Institute, MGH and Nature Medicine)
  • Place of Presentation: Stockholm
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Biochemistry and Biology of Leukotriene B4 receptors. (2006)
  • Author(s): Takao Shimizu
  • Organizer: Keystone Symposia on Eicosanoido in Inoflammation and Chironic Diseases
  • Place of Presentation: Snowbird Utah, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Comprehensive LC-MS analysis of lipid mediator generation. (2006)
  • Author(s): Yoshihiro Kita
  • Organizer: FASEB Summer Research Conferences-Phospholiphases
  • Place of Presentation: Vermont, Saxs on River, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Lipid mediators in health and diseases. (2005)
  • Author(s): 清水孝雄
  • Organizer: Pharmacology Seminar at University of California San Diego
  • Place of Presentation: La Jlla, CA
  • Year and Date: 2005-09-09
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Lipid mediators in health and diseases. (2005)
  • Author(s): Takao Shimizu
  • Organizer: Pharmacology Seminar at University of California San Diego
  • Place of Presentation: La Jolla, CA., USA
  • Year and Date: 2005-09-09
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Lysophopholipid/proton sensing receptors. (2005)
  • Author(s): 清水孝雄
  • Organizer: FASEB Summer Research Conference on Lysophospholid Mediators in Health and Diseases.
  • Place of Presentation: Snowmass, CO
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Cytosolic phospholipase A2 : biological significance and molecular diversity(Plenary lecture). (2005)
  • Author(s): 清水孝雄
  • Organizer: 9th International Conference on Eicosanoids and other Bioactive Lipids in Cancer Inflammation and Related
  • Place of Presentation: San Francisco, CA
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Lipidomics Approaches for a Comprehensive Analysis of Fatty Acid and Metabolites by LC/ESI-MS (2005)
  • Author(s): 北芳博
  • Organizer: 9th International Conference on Eicosanoids and other Bioactive Lipids in Cancer Inflammation and Related
  • Place of Presentation: San Francisco
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Lysophopholipid/proton sensing receptors. (2005)
  • Author(s): Takao Shimizu
  • Organizer: FASEB Summer Research Conference on Lysophospholid Mediators in Health and Diseases.
  • Place of Presentation: Snowmass, CO., USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Cytosolic phospholipase A2 : biological significance and molecular diversity (Plenary lecture). (2005)
  • Author(s): TaKao Shimizu
  • Organizer: 9th International Conference on Eicosanoids and other Bioactive Lipids in Cancer Inflammation and Related Diseases.
  • Place of Presentation: San Francisco CA., USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Lipidomics Approaches for a Comprehensive Analysis of Fatty Acid and Metabolites by LC/ESI-MS (2005)
  • Author(s): Yoshihiro Kita
  • Organizer: 9th International Conference on Eicosanoids and other Bioactive Lipids in Cancer Inflammation and Related Diseases.
  • Place of Presentation: San Francisco CA., USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Lipid signaling molecules in health and diseases. (2004)
  • Author(s): 清水孝雄
  • Organizer: Chancellor' s Award Lecture of Louisiana State University
  • Place of Presentation: New Orleans, LA, Louisiana State
  • Year and Date: 2004-05-19
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Lipid signaling molecules in health and diseases. (2004)
  • Author(s): Takao Shimizu
  • Organizer: Chancellor' s Award Lecture of Louisiana State University
  • Place of Presentation: Louisiana State University, New Orleans, LA. USA
  • Year and Date: 2004-05-19
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Pysiological roles of cPLA2 enzymes. (2004)
  • Author(s): 清水孝雄
  • Organizer: FASEB Summer Research Conference on Phospholipases Callaway
  • Place of Presentation: Pine Mountains, GA.
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Roles of cytosolic phospholipase A2 in vitro and in vivo (Plenary lecture) (2004)
  • Author(s): 清水孝雄
  • Organizer: 2nd International Conference on Phospholipase A2/8thInternational PAF Conference (Joint meeting)
  • Place of Presentation: Berlin
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Comprehensive analysis of macrophage lipid mediator production by liquidchromatography-e1 ectrospray ionization-tandem mass spectorometorv. (2004)
  • Author(s): 北芳博
  • Organizer: 2nd International Conference on Phospholipase A2/8thInternational PAF Conference (Joint meeting)
  • Place of Presentation: Berlin
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] LPS-priming enhances acetyl-CoA : lyso-PAF acetyltransferase activitiy independently of MyD88 and TRIF (2004)
  • Author(s): 進藤英雄
  • Organizer: 2nd International Conference on Phospholipase A2/8thInternational PAF Conference (Joint meeting)
  • Place of Presentation: Berlin
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Pysiological roles of cPLA2 enzymes. (2004)
  • Author(s): Takao Shimizu
  • Organizer: FASEB Summer Research Conference on Phospholipases Callaway
  • Place of Presentation: Pine Mountains, GA., USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Roles of cytosolic phospholipase A2 in vitro and in vivo (Plenary lecture) (2004)
  • Author(s): Takao Shimizu
  • Organizer: 2nd International Conference on Phospholipase A2/8th International PAF Conference (Joint meeting)
  • Place of Presentation: Berlin
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Comprehensive analysis of macrophage lipid mediator production by liquid chromatography-el ectrospray ionization-tandem mass spectorometory. (2004)
  • Author(s): Yoshihiro Kita
  • Organizer: 2nd International Conference on Phospholipase A2/8th International PAF Conference (Joint meeting)
  • Place of Presentation: Berlin
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] LPS-priming enhances acetyl-CoA : lyso-PAF acetyltransferase activitiy independently of MyD88 and TRIF (2004)
  • Author(s): Hideo Shindou
  • Organizer: 2nd International Conference on Phospholipase A2/8th International PAF Conference(Joint meeting)
  • Place of Presentation: Berlin
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Characterization and Biological Roles of Leukotrien B4 Receptors. (2003)
  • Author(s): 清水孝雄
  • Organizer: 8th International Conference Eicosanoid & Other Bioactive Lipids In Cancer, Inflammation and Related Diseases
  • Place of Presentation: Cicago, USA
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Characterization and Biological Roles of Leukotrie B4 Receotors. (2003)
  • Author(s): Takao Shimizu
  • Organizer: 8th International Conference Eicoanoid & Other Bioactive Lipids In cancer, Inflammation and Related Diseases
  • Place of Presentation: Cicago, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Tashiro, S., Sumi, T., Uozumi, N., Shimizu.T., Nakamura, T: "B-myb-dependent regulation of c-myc expression by cytosolic phospholipase A2"Journal of Biological Chemistry. 279(印刷中). (2004)
• [Publications] Okuno, T., Ago, H., Terawaki, K, Miyano, M., Shimizu, T., Yokomizo T.: "Helix 8 of the leukotriene B4 receptor is required for the conformational change to the low-affinity state after G-protein activation"Journal of Biological Chemistry. 278. 41500-41509 (2003)
• [Publications] Weijer, S., Leemans, J.C., Florquin, S., Shimizu, T., Ishii, S.: "Host response of platelet-activating factor receptor-deficient mice during pulmonary tuberculosis"Immunology. 109. 552-556 (2003)
• [Publications] Yamauchi, T.et al.: "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects"Nature. 423. 762-768 (2003)
• [Publications] Hegen, M., Shimizu T., Clark D.J.: "Cytosolic phospholipase A2α deficient mice are resistant to collagen-induced arthritis"Journal of Experimental Medicine. 197. 1297-1302 (2003)
• [Publications] Noguchi, K., Ishii, S., Shimizu, T.: "Identification of p2y9/GPR23 as a Novel G Protein-Coupled Receptor for Lysophosphatidic Acid, Structurally Distant from the Edg Family"Journal of Biological Chemistry. 278. 25600-25606 (2003)