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A Search for Risk Genes of Psychiatric Disorders

Research Project

Project/Area Number 17019029
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionTokyo Metropolitan Organization for Medical Research (2007-2009)
Mie University (2005-2006)

Principal Investigator

OKAZAKI Yuji  Tokyo Metropolitan Organization for Medical Research, 東京都精神医学総合研究所, 客員研究員 (40010318)

Co-Investigator(Kenkyū-buntansha) 佐々木 司  東京大学, 保健センター, 准教授 (50235256)
谷井 久志  三重大学, 大学院・医学系研究科, 准教授 (40346200)
加藤 忠史  独立行政法人理化学研究所, 精神疾患老化研究グルーフ, グループリーダ (30214381)
松本 直通 (松本 直道)  横浜市立大学, 大学院・医学(系)研究科(研究院), 教授 (80325638)
吉川 武男  独立行政法人理化学研究所, 分子精神科学研究チーム, チームリーダー (30249958)
功刀 浩  国立精神神経センター, 神経研究所, 部長 (40234471)
有波 忠雄  筑波大学, 大学院・人間総合科学研究科, 教授 (10212648)
染矢 俊幸  新潟大学, 医歯(薬)学・総合研究科, 教授 (50187902)
Research Collaborator 貝谷 久宣  医療法人和楽会, パニック障害研究センター
井上 顕  藤田保健衛生大学, 医学部
西村 幸香  東京大学、財団法人精神神経科学振興, 医学部
西田 淳志  財団法人東京都医学研究機構, 東京都精神医学総合研究所
梅景 正  東京大学, 保健センター
栃木 衛  東京大学, 大学院・医学系研究科
音羽 健司  東京大学, 大学院・医学系研究科
河村 代志也  東京大学, 大学院・医学系研究科
今村 明  長崎大学, 医歯薬学総合研究科
垣内 千尋  東京大学, 医学部附属病院・精神神経科
石渡 みずほ  独立行政法人理化学研究所, 脳科学総合研究センター
穐吉 条太郎  大分大学, 医学部
清水 栄司  千葉大学, 大学院・医学研究院
Project Period (FY) 2005 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥122,600,000 (Direct Cost: ¥122,600,000)
Fiscal Year 2009: ¥23,600,000 (Direct Cost: ¥23,600,000)
Fiscal Year 2008: ¥23,500,000 (Direct Cost: ¥23,500,000)
Fiscal Year 2007: ¥25,000,000 (Direct Cost: ¥25,000,000)
Fiscal Year 2006: ¥25,300,000 (Direct Cost: ¥25,300,000)
Fiscal Year 2005: ¥25,200,000 (Direct Cost: ¥25,200,000)
Keywordspanic disorder / risk genes / GWAS / SNPs / CNVs / CGH array / twin NIRS / twin / 900k array / 精神疾患 / パニック障害 / 病因遺伝子 / ゲノムスキャン(GWAS) / 双生児 / 相関解析 / ゲノムワイドスキャン / 500K SNPsチップ / 一卵性双生児不一致例 / 遺伝子発現差異解析 / CGHアレイ / 微小染色体構造異常 / 候補遺伝子 / 疾患感受性遺伝子 / 表現型不一致一卵性双生児 / 染色体構造異常スクリーニング / ゲノムスキャン / 相関研究 / 中間表現型 / SNPsチップ
Research Abstract

Panic disorder (PD) is characterized by the recurrence of anxiety attacks and anticipatory anxiety that causes extensive restriction in daily activities. It is known that 2% of general population suffers from the disorder and genetic factor plays a role in the causation. We have established the largest DNA sample in the world, and searched risk SNPs, CNVs and micro chromosomal abnormalities for PD using 900k SNPs chip and CGH arrays. Common CNVs on chromosome 11, 14, 19 were found to be associated with PD and further analysis is in progress. We also found hypo-activation of prefrontal cortex is a trait and intermediate phenotype of PD, through NIRS measurements comparing between twins from identical twin pairs discordant for PD and between PD patients with and without family history.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (75 results)

All 2010 2009 2008 2007 2006 2005 Other

All Journal Article (44 results) (of which Peer Reviewed: 21 results) Presentation (22 results) Book (9 results)

  • [Journal Article] パニック障害の遺伝子.2010

    • Author(s)
      音羽健司、佐々木司
    • Journal Title

      分子精神医学 10

      Pages: 46-50

    • Related Report
      2009 Final Research Report
  • [Journal Article] パニック障害に対する薬物療法.2010

    • Author(s)
      佐々木司
    • Journal Title

      内科 105

      Pages: 259-262

    • Related Report
      2009 Final Research Report
  • [Journal Article] パニック障害の遺伝子2010

    • Author(s)
      音羽健司、佐々木司
    • Journal Title

      分子精神医学 10

      Pages: 46-50

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Asymmetry of prefrontal cortex activities and catechol-O-methyltransferase Val158Met genotype in patients with panic disorder during a verbal fluency task: near infrared spectroscopy study.2009

    • Author(s)
      Tanii H, Nishimura Y, Inoue K, Koshimizu H, Matsumoto R, Takami T, Hara N, Nishida A, Okada M, Kaiya H, Okazaki Y
    • Journal Title

      Neurosci Lett. 452

      Pages: 63-67

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study of panic disorder in the Japanese population.2009

    • Author(s)
      Otowa T, Yoshida E, Yasuda S, Sugaya N, Nishimura Y, Inoue K, Tochigi M, Umekage T, Miyagawa T, Nishida N, Tokunaga K, Tanii H, Sasaki T, Kaiya H, Okazaki Y
    • Journal Title

      J Hum Genet. 54

      Pages: 122-126

    • NAID

      10030729336

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between the prefrontal function during a cognitive task and the severity of the symptoms in patients with panic disorder: a multi-channel NIRS study.2009

    • Author(s)
      Nishimura Y, Tanii H, Hara N, Inoue K, Kaiya H, Nishida A, Okada M, Okazaki Y
    • Journal Title

      Psy Res. - Neuroimaging 172(2)

      Pages: 168-172

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Specific panic attack symptoms in panic disorder patients with putative genetic factor.2009

    • Author(s)
      Nishimura Y, Tanii H, Hara N, Inoue K, Nishida A, Okada M, Kaiya H, Okazaki Y
    • Journal Title

      Psy Clin Neurosci 63

      Pages: 251-252

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] No association between the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene and panic disorder in Japanese population.2009

    • Author(s)
      Otowa T, Shimada T, Kawamura Y, Liu X, Inoue K, Sugaya N, Minato T, Nakagami R, Tochigi M, Umekage T, Kasai K, Kato N, Tanii H, Okazaki Y, Kaiya H, Sasaki T.
    • Journal Title

      J Hum Genet 54(8)

      Pages: 437-9

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intrasubject reproducibility of prefrontal cortex activities during a verbal fluency task over two repeated sessions using multi-channel near-infrared spectroscopy.2009

    • Author(s)
      Yu Kakimoto, Yukika Nishimura, Naomi Hara, Motohiro Okada, Hisashi Tanii, Yuji kazaki.
    • Journal Title

      Psychiatr Clin Neurosci. 63(4)

      Pages: 491-499

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] パニック障害の全ゲノム関連研究.2009

    • Author(s)
      音羽健司、佐々木司
    • Journal Title

      医学のあゆみ 229

      Pages: 191-194

    • Related Report
      2009 Final Research Report
  • [Journal Article] 不安障害とゲノミックス.2009

    • Author(s)
      音羽健司、佐々木司
    • Journal Title

      臨床精神医学 38

      Pages: 1021-29

    • Related Report
      2009 Final Research Report
  • [Journal Article] Specific panic attack symptoms in panic disorder patients with putative genetic factor.2009

    • Author(s)
      Nishimura Y, Tanii H, Hara N, Inoue K, Nishida A, Okada M, Kaiya H, Okazaki Y
    • Journal Title

      Psychiatry Clin Neurosci 63

      Pages: 251-252

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between the prefrontal function during a cognitive task and the severity of the symptoms in patients with panic disorder : a multi-channel NIRS study.2009

    • Author(s)
      Nishimura Y, Tanii H, Hara N, Inoue K, Kaiya H, Nishida A, Okada M, Okazaki Y
    • Journal Title

      Psychiatry Research - Neuroimaging 172

      Pages: 168-172

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Replication of a genome-wide association study of panic disorder in a Japanese population.2009

    • Author(s)
      Otowa T, Tanii H, Sugaya N, Yoshida E, Inoue K, Yasuda S, Shimada T, Kawamura Y, Tochigi M, Minato T, Umekage T, Miyagawa T, Nishida N, Tokunaga K, Okazaki Y, Kaiya H, Sasaki T
    • Journal Title

      J Hum Genet 55

      Pages: 91-96

    • NAID

      10030733614

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study of panic disorder in the Japanese population.2009

    • Author(s)
      Otowa T, Yoshida E, Sugaya N, Yasuda S, Nishimura Y, Inoue K, Tochigi T, Umekage T, Miyagawa T, Nishida N, Tokunaga K, Tanii H, Sasaki T^*, Kaiya H, Okazaki Y.
    • Journal Title

      J Hum Genet 54 : 54

      Pages: 122-126

    • NAID

      10030729336

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetry of prefrontal cortex activities and catechol-O-methyttransferase Val158 Met genotype in patients with panic disorder during a verbal fluency task : near infrared spectroscopy study.2009

    • Author(s)
      Tanii H, Nishimura Y, Inoue K, Koshimizu H, Matsumoto R, Takami T, Hara N, Nishida A, Okada M, Kaiya H, Okazaki Y
    • Journal Title

      Neuroscience Letters 452

      Pages: 63-67

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] No association between the Va166Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene and panic disorder in Japanese population.2009

    • Author(s)
      Otowa T, Shimada T, Kawamura Y, Liu X, Inoue K, Sugaya N, Minato T, Nakagami R, Tochigi M, Umekage T, Kasai K, Kato N, Tanii H, Okazaki Y, Kaiya H, Sasaki T
    • Journal Title

      J Hum Genet 54

      Pages: 437-439

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 不安障害とゲノミックス2009

    • Author(s)
      音羽健司、佐々木司
    • Journal Title

      臨床精神医学 38

      Pages: 1021-1029

    • Related Report
      2009 Annual Research Report
  • [Journal Article] パニック障害の全ゲノム関連研究2009

    • Author(s)
      音羽健司、佐々木司
    • Journal Title

      医学のあゆみ 229

      Pages: 191-194

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Genome-wide association study of panic disorder in the Japanese population.2009

    • Author(s)
      Otowa T, Yoshida E, Sugaya N, Yasuda S, Nishimura Y, Inoue K, Tochigi M, Umekage T. Miyagawa T, Nishida N, Tokunaga K, Tanii H, Sasaki T, Kaiya H, Okazaki Y.
    • Journal Title

      J Hum Genet. 2009;54(2):122-6 54

      Pages: 122-126

    • NAID

      10030729336

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] パニック障害2008

    • Author(s)
      西村幸香・岡崎祐士
    • Journal Title

      精神疾患と脳画像(福田正人編)

    • Related Report
      2008 Annual Research Report
  • [Journal Article] パニック障害研究の現状と展望.2007

    • Author(s)
      谷井久志・西村幸香・音羽健司・佐々木司・貝谷久宣・岡崎祐士
    • Journal Title

      実験医学 25

      Pages: 167-172

    • Related Report
      2009 Final Research Report
  • [Journal Article] パニック障害研究の現状と展望2007

    • Author(s)
      谷井 久志・西村 幸香・音羽 健司・佐々木 司・貝谷 久宣・岡崎 祐士
    • Journal Title

      実験医学 25

      Pages: 167-172

    • Related Report
      2007 Annual Research Report
  • [Journal Article] パニック障害2007

    • Author(s)
      岡崎祐士, 谷井久志, 貝谷久宣, 音羽健司, 佐々木司
    • Journal Title

      実験医学 25巻(印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] パニック障害の遺伝子探索2007

    • Author(s)
      谷井久志, 井上顕, 西村幸香, 梶木直美, 貝谷久宣, 佐々木司, 岡崎祐士
    • Journal Title

      脳と精神の医学 18巻(1号)

      Pages: 1-7

    • NAID

      10029854062

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 最新医学別冊 新しい診断と治療の ABC 40/精神3 パニック障害(竹内龍雄編)病因・病態仮説 : 家族・遺伝研究2006

    • Author(s)
      谷井久志, 田原淳輔, 井上顕, 西村幸香, 岡崎祐士
    • Journal Title

      最新医学別冊 62巻

      Pages: 59-72

    • Related Report
      2006 Annual Research Report
  • [Journal Article] パニック障害の遺伝子探索2006

    • Author(s)
      谷井久志, 岡崎祐士
    • Journal Title

      脳と精神の医学 17巻(2号)

      Pages: 115-126

    • NAID

      10029853054

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Panic disorder and suicide in Mie Prefecture, Japan2006

    • Author(s)
      Inoue K, Tanii H, Fukunaga T, Abe S, Nishimura Y, Kajiki N, Yokoyama C, Nishida A, Tawara J, Kaiya H, Nata M, Okazaki Y
    • Journal Title

      Psychirtr Clin Neurosci. 60

      Pages: 640-641

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Frontal hypoactivation during a word fluency task in patients with panic disorder : a multichannel near-infrared spectroscopy study2006

    • Author(s)
      Nishimura Y, Okazaki Y, Tanii H, Inoue K, Kajiki N, Tawara J, Nishida A, Kaiya H
    • Journal Title

      Int Congr Ser 1287 : 293-7. (2006, 04) 1287

      Pages: 293-297

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia.2005

    • Author(s)
      Kato T, Iwayama Y, Kakiuchi C, Iwamoto K, Yamada K, Minabe Y, Nakamura K, Mori N, Fujii K, Nanko S, Yoshikawa T.
    • Journal Title

      Mol Psychiatry 10

      Pages: 1045-55

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic or epigenetic difference causing discordance between monozygotic twins as a clue to molecular basis of mental disorders.2005

    • Author(s)
      Tadafumi Kato, Kazuya Iwamoto, Chihiro Kakiuchi, Go Kuratomi, Yuji Okazaki
    • Journal Title

      Mol Psychiatry 10(7)

      Pages: 622-630

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Factors associated with the development of panic attack and panic disorder: a survey in the Japanese population.2005

    • Author(s)
      Kaiya H, Umekage T, Harada S, Okazaki Y, Sasaki T.
    • Journal Title

      Psychiatry and Clinical Neurosciences. 59

      Pages: 177-82

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional polymorphisms of HSPA5 : Possible association with bipolar disorder.2005

    • Author(s)
      Kakiuchi C, (13人), Kato T
    • Journal Title

      Biochemical and Biophysical Research Communications 336

      Pages: 1136-1143

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Genetic or epigenetic difference causing discordance between monozygotic twins as a clue to molecular basis of mental disorders2005

    • Author(s)
      Kato T, (3人), Okazaki Y
    • Journal Title

      Molecular Psychiatry 10(7)

      Pages: 622-630

    • Related Report
      2005 Annual Research Report
  • [Journal Article] RNAiまたはRNA干渉2005

    • Author(s)
      谷井久志, 岡崎祐士
    • Journal Title

      臨床精神医学 33

      Pages: 838-839

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Frontal lobe dysfunction in panic disorder: a comparison of multichannnel near-infrared spectroscopy in monozygotic twins discordant for panic disorder.

    • Author(s)
      Tanii H, Nishimura Y, Inoue K, Hara N, Nishida A, Okada M, Kaiya H, Okazaki Y
    • Journal Title

      europsychiatry Clin Neurosci (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article]

    • Author(s)
      Yukika Nishimura, Koji Sugisaki, Noriko Hattori, Yasushi Inokuchi, Masayuki Komachi, Yoshihiro Nishimura, Mariko Ogawa, Motohiro Okada, Yuji Okazaki, Waro Taki, Tetsuro Yamamoto, Etsuko Yoshida, Seiki Ayano.
    • Journal Title

      Brain Res (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] BP1 induces WFS1 through endoplasmic reticulum stress response element (ERSE)-like motif in SH-SY5Y cells.

    • Author(s)
      Kakiuchi C, Ishiwata M, Kato T
    • Journal Title

      Journal of Neurochemistry (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frontal lobe dysfunction in panic disorder : a comparison of multichannnel near-infrared spectroscopy in monozygotic twins discordant for panic disorder.

    • Author(s)
      Tanii H, Nishimura Y, Inoue K, Hara N, Nishida A, Okada M, Kaiya H, Okazaki Y
    • Journal Title

      Neuropsychiatry Clin Neurosci (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Replication of a genome-wide association study of panic disorder in a Japanese population.

    • Author(s)
      Otowa T, Tanii H, Sugaya N, Yoshida E, Inoue K, Yasuda S, Shimada T, Kawamura Y, Tochigi M, Umekage T, Minato T, Miyagawa T, Nishida N, Tokunaga K, Okazaki Y, Kaiya H, Sasaki T
    • Journal Title

      J Hum Genet (in press)

    • NAID

      10030733614

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suicide in panic disorder -Review-

    • Author(s)
      Inoue K, Tanii H, Nishimura Y, Masaki M, Yokoyama C, Kajiki N, Nishida A, Fukunaga T, Nata M, Abe S, Okazaki Y, Kaiya H
    • Journal Title

      Int Med Journal (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A family-based and case-control association study of SOX10 in schizophrenia.

    • Author(s)
      Iwamoto K, (5人), Kato T
    • Journal Title

      American Journal of Medical Genetics(Neuropsychiatric Genetics) In press

    • Related Report
      2005 Annual Research Report
  • [Journal Article] XBP1 induces WFS1 through endoplasmic reticulum stress response element (ERSE)-like motif in SH-SY5Y cells.

    • Author(s)
      Kakiuchi C, Ishiwata M, Kato T
    • Journal Title

      Journal of Neurochemistry In press

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Panic disorder and suicide in Mie Prefecture,

    • Author(s)
      Inoue K, Tanii H, (9人), Okazaki Y
    • Journal Title

      Psychiatry and Clinical Neurosciences In press

    • Related Report
      2005 Annual Research Report
  • [Presentation] :Bio-Psycho-Social-Spiritual Perspect of Panic Disorder, Up to Date of Psychobiology2010

    • Author(s)
      谷井久志
    • Organizer
      第2回日本不安障害学会学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-06
    • Related Report
      2009 Final Research Report
  • [Presentation] Bio-psycho-Social -Spiritual perspect of Panic Disorder, Up to Date of Psychobiology2010

    • Author(s)
      谷井久志
    • Organizer
      第2回日本不安障害学会学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Replication of a genome-wide association study of panic disorder in a Japanese population2009

    • Author(s)
      Takeshi Otowa, Takanobu Minato, Nagisa Sugaya, Ken Inoue, Takafumi Shimada, Yosh iya Kawamura, Mamoru Tochigi, Tadashi Umekage, Hisashi Tanii, Taku Miyagawa, Nao Nishida, Katsushi Tokunaga, Yuji Okazaki, Hisanobu Kaiya, Tsukasa Sasaki
    • Organizer
      XVII World Congress of Psychiatric Genetics
    • Place of Presentation
      San Diego, California,USA
    • Year and Date
      2009-11-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Replication of a genome-wide association study of panic disorder in a Japanese population2009

    • Author(s)
      音羽健司、湊崇暢、菅谷渚、井上顕、島田隆史、河村代志也、栃木衛、梅景正、谷井久志、宮川卓、西田奈央、徳永勝士、岡崎祐士、貝谷久宣、佐々木司
    • Organizer
      第54回日本人類遺伝学会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] パニック障害における広場恐怖やうつ病の合併に関する性格特性と性差に関する検討.2009

    • Author(s)
      谷井久志、石栗知美、西村幸香、原直美、井上顕、岡田元宏、貝谷久宣、岡崎祐士
    • Organizer
      第105回日本精神神経学会
    • Place of Presentation
      神戸市
    • Year and Date
      2009-08-21
    • Related Report
      2009 Final Research Report
  • [Presentation] パニック障害における広場恐怖やうつ病の合併に関する性格特性と性差に関する検討2009

    • Author(s)
      谷井久志、石栗知美、西村幸香、原直美、井上顕、岡田元宏、貝谷久宣、岡崎祐士
    • Organizer
      第105回日本精神神経学会
    • Place of Presentation
      神戸
    • Year and Date
      2009-08-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] パニック障害におけるSigma1受容体遺伝子多型とNIRSによる脳機能測定の関連性について.2009

    • Author(s)
      谷井久志、西村幸香、井上顕、細川琴美、小西喜昭、貝谷久宣、岡崎祐士
    • Organizer
      第11回光脳機能イメージング研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-18
    • Related Report
      2009 Final Research Report
  • [Presentation] パニック障害におけるSigma 1受容体遺伝子多型とNIRSによる脳機能測定の関連性について2009

    • Author(s)
      谷井久志、西村幸香、井上顕、細川琴美、小西喜昭、貝谷久宣、岡崎祐士
    • Organizer
      第11回光脳機能イメージング研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] パ6ニック障害における遺伝子多型と知的機能検査に関する検討.2009

    • Author(s)
      谷井久志、細川琴美、西村幸香、石栗知美、前田阿紀、萩原康輔、井上顕、小西喜昭、原直美、岡田元宏、貝谷久宣、岡崎祐士
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      京都市
    • Year and Date
      2009-04-23
    • Related Report
      2009 Final Research Report
  • [Presentation] パニック障害における遺伝子多型と知的機能検査に関する検討2009

    • Author(s)
      谷井久志、細川琴美、西村幸香、石栗知美、前田阿紀、萩原康輔、井上顕、小西喜昭、原直美、岡田元宏、貝谷久宣、岡崎祐士
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      京都
    • Year and Date
      2009-04-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Re plication of a genome-wide association study of panic disorder in a Japanese pop ulation.2009

    • Author(s)
      Takeshi Otowa, Takanobu Minato, Nagisa Sugaya, Ken Inoue, Takafumi Shimada, Yosh iya Kawamura, Mamoru Tochigi, Tadashi Umekage, Hisashi Tanii, Taku Miyagawa, Nao Nishida, Katsushi Tokunaga, Yuji Okazaki, Hisanobu Kaiya, Tsukasa Sasaki
    • Organizer
      XVII World Congress of Psychiatric Genetics
    • Place of Presentation
      San Diego, California, U. S
    • Related Report
      2009 Final Research Report
  • [Presentation] Association between sigma1 receptor gene A61C (GIn2Pro) and serotonin receptor 1A promoter -1019C>G polymorphism and panic disorder in Japanese population2009

    • Author(s)
      Yoshiaki Konishi, Hisashi Tanii, Takeshi Otowa, Tsukasa Sasaki, Hisanobu Kaiya, Yuji Okazaki
    • Organizer
      XVIIth World Congress of psychiatric Genetics
    • Place of Presentation
      San Diego, California,USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Risk Genes for Panic Disorder: a GWAS Study.2008

    • Author(s)
      Tanii H, Sasaki T, Otowa T, Kato T, Yoshikawa T, Arinami T, Kunugi H, Someya T, Matumoto N, Kaiya H, Okazaki Y
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      富山市
    • Related Report
      2009 Final Research Report
  • [Presentation] Genome-wide association study of panic disorderin Japanese.2008

    • Author(s)
      Okazaki Y, Sasaki T, Tanii H, Kaiya H
    • Organizer
      2008 International Conference on Pharmacogenomics.
    • Place of Presentation
      Busan, Korea.
    • Related Report
      2009 Final Research Report
  • [Presentation] Genome-wide association study of panic disorder in Japanese2008

    • Author(s)
      Okazaki Y, Sasaki T, Tanii H, Kaiya H
    • Organizer
      2008 International Conference on Pharmacogenomics
    • Place of Presentation
      Busan, Korea
    • Related Report
      2008 Annual Research Report
  • [Presentation] Risk Genes for Panic Disorder : a GWAS Study2008

    • Author(s)
      Tanii H, Sasaki T, Otowa T, Kato T, Yoshikawa T, Arinami T, Kunugi H, Someya T, Matumoto N, Kaiya H, Okazaki Y
    • Organizer
      第51回日本神経化学会大会
    • Place of Presentation
      富山市
    • Related Report
      2008 Annual Research Report
  • [Presentation] シンポジウム「網羅的解析から創薬へ」パニック障害の全ゲノム解析2007

    • Author(s)
      佐々木司
    • Organizer
      第15回日本精神・行動遺伝医学会
    • Place of Presentation
      小平市
    • Year and Date
      2007-11-17
    • Related Report
      2009 Final Research Report
  • [Presentation] パニック障害患者における初発パニック発作症状の遺伝学的解析2007

    • Author(s)
      高見鉄平・西村幸香・谷井久志・貝谷久宣・岡崎祐士
    • Organizer
      第15回日本精神・行動遺伝医学会
    • Place of Presentation
      小平市
    • Year and Date
      2007-11-17
    • Related Report
      2009 Final Research Report
  • [Presentation] パニック障害患者における初発パニック発作症状の遺伝学的解析2007

    • Author(s)
      高見 鉄平・西村 幸香・谷井 久志・貝谷 久宣・岡崎 祐士
    • Organizer
      第15回日本精神・行動遺伝医学会
    • Place of Presentation
      東京都小平市・国立精神神経センター
    • Year and Date
      2007-11-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] シンポジウム「網羅的解析から創薬へ」パニック障害の全ゲノム解析2007

    • Author(s)
      佐々 木司
    • Organizer
      第15回日本精神・行動遺伝医学会
    • Place of Presentation
      東京都小平市・国立精神神経センター
    • Year and Date
      2007-11-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] パニック障害に関する一卵性双生児不一致ペアに関する検討.2007

    • Author(s)
      谷井久志・井上顕・西村幸香・横山知加・加藤忠史・岡田元宏・貝谷久宣・岡崎祐士
    • Organizer
      第29回日本生物学的精神医学会・第37回日本神経精神薬理学会合同年会
    • Place of Presentation
      札幌
    • Year and Date
      2007-07-13
    • Related Report
      2009 Final Research Report
  • [Presentation] パニック障害に関する-卵性双生児不一致ペアに関する検討2007

    • Author(s)
      谷井 久志・井上 顕・西村 幸香・横由 知加・加藤 忠史・岡田 元宏・貝谷 久宣・岡崎 祐士
    • Organizer
      第29回日本生物学的精神医学会・第37回日本神経精神薬理学会合同年会
    • Place of Presentation
      札幌・札幌コンベンションセンター
    • Year and Date
      2007-07-13
    • Related Report
      2007 Annual Research Report
  • [Book] 遺伝子解析(松本英夫、飯田順三編, 子どもの精神病性障害. I. 統合失調症)2009

    • Author(s)
      栃木衛、佐々木司
    • Publisher
      中山書店
    • Related Report
      2009 Final Research Report
  • [Book] 精神疾患とNIRS(福田正人編, 2章 精神医学におけるNIRS、4.データの再現性)2009

    • Author(s)
      西村幸香・滝沢龍・笠井清登
    • Publisher
      中山書店
    • Related Report
      2009 Final Research Report
  • [Book] 精神疾患とNIRS(福田正人編, 3章 精神疾患への応用、7.パニック障害・不安障害)2009

    • Author(s)
      西村幸香・横山知加・谷井久志・笠井清登・貝谷久宣・岡崎祐士
    • Publisher
      中山
    • Related Report
      2009 Final Research Report
  • [Book] 子どもの精神病性障害.I.統合失調症(松本英夫、飯田順三編)(中山書店)2009

    • Author(s)
      栃木衛、佐々木司
    • Total Pages
      67
    • Publisher
      遺伝子解析
    • Related Report
      2009 Annual Research Report
  • [Book] 図説 分子病態学(一瀬白帝・鈴木宏冶編, 疾患の分子病態学-統合失調症、双極性障害)2008

    • Author(s)
      岡崎祐士・糸川昌成
    • Related Report
      2009 Final Research Report
  • [Book] 精神疾患と脳画像(福田正人編, パニック障害)2008

    • Author(s)
      西村幸香・岡崎祐士
    • Related Report
      2009 Final Research Report
  • [Book] 図説 分子病態学(一瀬白帝・鈴木宏治編)2008

    • Author(s)
      岡崎 祐士・糸川 昌成
    • Publisher
      疾患の分子病態学-統合失調症、双極性障害
    • Related Report
      2007 Annual Research Report
  • [Book] パニック障害の治療ガイドライン2007

    • Author(s)
      谷井久志, 梶木直美, 西村幸香, 貝谷久宣, 岡崎祐士
    • Publisher
      医学書院
    • Related Report
      2006 Annual Research Report
  • [Book] Hypoactivation during a word fluency task in patients with panic disorder : A multichannel near-infrared spectroscopy study. International Congress Series

    • Author(s)
      Nishimura Y., Okazaki Y., Tanii H.et al.
    • Publisher
      (in press)
    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2018-03-28  

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