| Co-Investigator(Kenkyū-buntansha) |
YUZAKI Michisuke 慶應義塾大学, 医学部, 教授 (40365226)
MIYAWAKI Atsushi 独立行政法人理化学研究所, 細胞機能探索技術開発チーム, チームリーダー (80251445)
YAMASHIMA Tetsumori 金沢大学, 大学院・医学研究科, 准教授 (60135077)
SAWAMOTO Kazunobu 名古屋市立大学, 大学院・医学研究科, 教授 (90282350)
ITOHARA Shigeyoshi 独立行政法人理化学研究所, 行動遺伝学技術開発チーム, チームリーダー (60252524)
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| Budget Amount *help |
¥568,100,000 (Direct Cost: ¥437,000,000、Indirect Cost: ¥131,100,000)
Fiscal Year 2009: ¥114,140,000 (Direct Cost: ¥87,800,000、Indirect Cost: ¥26,340,000)
Fiscal Year 2008: ¥114,140,000 (Direct Cost: ¥87,800,000、Indirect Cost: ¥26,340,000)
Fiscal Year 2007: ¥114,140,000 (Direct Cost: ¥87,800,000、Indirect Cost: ¥26,340,000)
Fiscal Year 2006: ¥114,140,000 (Direct Cost: ¥87,800,000、Indirect Cost: ¥26,340,000)
Fiscal Year 2005: ¥111,540,000 (Direct Cost: ¥85,800,000、Indirect Cost: ¥25,740,000)
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| Research Abstract |
The discovery of neurogenesis in adult mammalian brains showed the possible application of neural stem cells (NSCs) to regenerative medicine of the nervous system. In this study, we tried to elucidate the physiological functions of two proteins that we had identified as regulators of NSCs, namely the RNA-binding protein Musashi-1 and the sugar chain-binding secretory protein Galectin-1, in adult mammalian brains. We also established a transgenic mouse system ("Color Timer") for visualizing neurogenesis with fluorescence.
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