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Molecular mechanisms of neuropathic pain

Research Project

Project/Area Number 19300121
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionHyogo College of Medicine

Principal Investigator

NOGUCHI Koichi  Hyogo College of Medicine, 医学部, 教授 (10212127)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2009: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2008: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2007: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Keywords後根神経節 / MAPキナーゼ / 脊髄後角 / ATP受容体 / 疼痛行動 / 神経障害 / 背髄後角
Research Abstract

In order to examine the novel mechanism of neuropathic pain, we have used the rat model of neuropathic pain and explored the expression and the role of several molecules in nociceptive pathway. As a result, we have found that some intracellular signaling molecules, ATP receptors and some cytokines have important roles in dorsal root ganglion neurons, spinal dorsal horn neurons and spinal glial cells. These results were published in international high-level journals. We believe that these findings are expected as novel seeds for development of new therapeutic drug of neuropathic pain.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (81 results)

All 2010 2009 2008 2007 Other

All Journal Article (41 results) (of which Peer Reviewed: 41 results) Presentation (37 results) Book (3 results)

  • [Journal Article] Expression of transient receptor potential ankyrin 1 (TRPA1) in the rat trigeminal sensory afferents and spinal dorsal horn2010

    • Author(s)
      Kim YS, Son JY, Kim TH, Paik SK, Dai Y, Noguchi K, Ahn DK, Bae YC
    • Journal Title

      J Comp Neurol 518

      Pages: 687-98

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain2010

    • Author(s)
      Okubo M, Yamanaka H, Kobayashi K, Noguchi K
    • Journal Title

      Glia 58

      Pages: 599-610

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain.2010

    • Author(s)
      Okubo M, et.al.
    • Journal Title

      Glia 58

      Pages: 599-610

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of TRPA1 receptor in the rat trigeminal sensory afferents and spinal dorsal horn2010

    • Author(s)
      Yun Sook Kim., et.al.
    • Journal Title

      J.Comp.Neurol. 518

      Pages: 687-698

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transient receptor potential A1 mediates gastric distention-induced visceral pain in rats2009

    • Author(s)
      Kondo T, Obata K, Miyoshi K, Sakurai J, Tanaka J, Miwa H, Noguchi K
    • Journal Title

      Gut 58

      Pages: 1342-52

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transient receptor potential A1 mediates gastric distention-induced visceral pain in rats2009

    • Author(s)
      Kondo T., et.al.
    • Journal Title

      Gut 58

      Pages: 1342-1352

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential activation of p38 and extracellular signal-regulated kinase in spinal cord in a model of bee venom-induced inflammation and hyperalgesia2008

    • Author(s)
      Cui, X.Y., Dai, Y., Wang, S.L., Yamanaka, H., Kobayashi, K., Obata, K., Chen, J., Noguchi, K
    • Journal Title

      Mol. Pain 4

      Pages: 17-17

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of extracellular signal-regulated protein kinase in sensory neurons after noxious gastric distention and its involvement in acute visceral pain in rats2008

    • Author(s)
      Sakurai, J., Obata, K., Ozaki, N., Tokunaga, A., Kobayashi, K., Yamanaka, H., Dai, Y., Kondo, T., Miyoshi, K., Sugiura, Y., Matsumoto, T., Miwa, H., Noguchi, K
    • Journal Title

      Gastroenterology 134

      Pages: 1094-1103

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain2008

    • Author(s)
      Wang, S., Dai, Y., Fukuoka, T., Yamanaka, H., Kobayashi, K., Obata, K., Cui, X., Tominaga, M., Noguchi, K
    • Journal Title

      Brain 131

      Pages: 1241-1251

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain2008

    • Author(s)
      Kobayashi, K., Yamanaka, H., Fukuoka, T., Dai, Y., Obata, K., Noguchi, K
    • Journal Title

      J. Neurosci 28

      Pages: 2892-2902

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transforming growth factor-activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injury2008

    • Author(s)
      Katsura, H., Obata, K., Miyoshi, K., Kondo, T., Yamanaka, H., Kobayashi, K., Dai, Y., Fukuoka, T., Sakagami, M., Noguchi, K
    • Journal Title

      Glia 56

      Pages: 723-733

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative study of the distribution of the alpha-subunits of voltage-gated sodium channels in normal and axotomized rat dorsal root ganglion neurons2008

    • Author(s)
      Fukuoka, T., Kobayashi, K., Yamanaka, H., Obata, K., Dai, Y., Noguchi, K
    • Journal Title

      J. Comp. Neurol 510

      Pages: 188-206

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury2008

    • Author(s)
      Miyoshi, K., Obata, K., Kondo, T., Okamura, H., Noguchi, K
    • Journal Title

      J. Neurosci 28

      Pages: 12775-12787

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury.2008

    • Author(s)
      Miyoshi, K., et. al.
    • Journal Title

      J. Neurosci. 28

      Pages: 12775-12787

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative study of the distribution of the alpha-subunits of voltage-gated sodium channels in normal and axotomized rat dorsal root ganglion neurons.2008

    • Author(s)
      Fukuoka, T., et. al.
    • Journal Title

      J. Comp. Neurol. 510

      Pages: 188-206

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transforming growth factor-activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injury.2008

    • Author(s)
      Katsura, H., et. al.
    • Journal Title

      Glia 56

      Pages: 723-733

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain.2008

    • Author(s)
      Kobayashi, K., et. al.
    • Journal Title

      J. Neurosci. 28

      Pages: 2892-2902

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1 : a molecular mechanism of inflammatory pain.2008

    • Author(s)
      Wang, S., et. al.
    • Journal Title

      Brain 131

      Pages: 1241-1251

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor 3 contributes to spinal glial activation and tactile a llodynia after nerve injury.2008

    • Author(s)
      Obata, K., et. al.
    • Journal Title

      J. Neurochem. 105

      Pages: 2249-2259

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of extracellular signal-regulated protein kinase in sensory neurons after noxious gastric distention and its involvement in acute visceral pain in rats.2008

    • Author(s)
      Sakurai, J., et. al.
    • Journal Title

      Gastroenterology 134

      Pages: 1094-1103

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential activation of p38 and extracellular signal-regulated kinase in spinal cord in a model of bee venom-induced inflammation and hyperalgesia.2008

    • Author(s)
      Cui, X. Y., et. al.
    • Journal Title

      Mol. Pain

      Pages: 4-17

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 神経障害性疼痛における一次知覚ニューロンの役割2008

    • Author(s)
      小畑浩一, 他
    • Journal Title

      ペインクリニック 29

      Pages: 170-178

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 神経因性疼痛の分子メカニズム.2008

    • Author(s)
      小畑浩一, 他
    • Journal Title

      Brain and Nerve 60

      Pages: 483-492

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transforming growth factor-activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injury2008

    • Author(s)
      Katsura, H., et. al.
    • Journal Title

      Glia (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain2008

    • Author(s)
      Kobayashi, K., et. al.
    • Journal Title

      J.Neurosci 28

      Pages: 2892-2902

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1:a molecular mechanism of inflammatory pain2008

    • Author(s)
      Wang, S., et. al.
    • Journal Title

      Brain (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Axotomy increases plasma membrane Ca2+ pump isoform4 in primary afferent neurons2007

    • Author(s)
      Ogura, H., Tachibana, T., Yamanaka, H., Kobayashi, K., Obata, K., Dai, Y., Yoshiya, S., Noguchi, K
    • Journal Title

      Neuroreport 18

      Pages: 17-22

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alternation of the cell adhesion molecule L1 expression in a specific subset of primary afferent neurons contributes to neuropathic pain2007

    • Author(s)
      Yamanaka, H., Obata, K., Kobayashi, K., Dai, Y., Fukuoka, T., Noguchi, K
    • Journal Title

      Eur. J. Neurosci 25

      Pages: 1097-1111

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tissue type plasminogen activator induced in rat dorsal horn astrocytes contributes to mechanical hypersensitivity following dorsal root injury2007

    • Author(s)
      Kozai, T., Yamanaka, H., Dai, Y., Obata, K., Kobayashi, K., Mashimo, T., Noguchi, K
    • Journal Title

      Glia 55

      Pages: 595-603

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intensity-dependent activation of extracellular signal-regulated protein kinases 5 in sensory neurons contributes to pain hypersensitivity2007

    • Author(s)
      Mizushima, T., Obata, K., Katsura, H., Sakurai, J., Kobayashi, K., Yamanaka, H., Dai, Y., Fukuoka, T., Mashimo, T., Noguchi, K
    • Journal Title

      J. Pharmacol. Exp. Ther 321

      Pages: 28-34

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of extracellular signal-regulated protein kinases 5 in spinal microglia and primary sensory neurons for neuropathic pain2007

    • Author(s)
      Obata, K., Katsura, H., Mizushima, T., Sakurai, J., Kobayashi, K., Yamanaka, H., Dai, Y., Fukuoka, T., Noguchi, K
    • Journal Title

      J. Neurochem 102

      Pages: 1569-1584

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of extracellular signal-regulated protein kinases 5 in primary afferent neurons contributes to heat and cold hyperalgesia after inflammation2007

    • Author(s)
      Katsura, H., Obata, K., Mizushima, T., Sakurai, J., Kobayashi, K., Yamanaka, H., Dai, Y., Fukuoka, T., Sakagami, M., Noguchi, K
    • Journal Title

      J. Neurochem 102

      Pages: 1614-1624

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frequency-dependent ERK phosphorylation in spinal neurons by electric stimulation of the sciatic nerve and the role in electrophysiological activity2007

    • Author(s)
      Fukui, T., Dai, Y., Iwata, K., Kamo, H., Yamanaka, H., Obata, K., Kobayashi, K., Wang, S., Cui, X., Yoshiya, S., Noguchi, K
    • Journal Title

      Mol. Pain 3

      Pages: 18-18

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain2007

    • Author(s)
      Dai, Y., Wang, S., Tominaga, M., Yamamoto, S., Fukuoka, T., Higashi, T., Kobayashi, K., Obata, K., Yamanaka, H., Noguchi, K
    • Journal Title

      J. Clin. Invest 117

      Pages: 1979-1987

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intensity-dependent activation of extracellular signal-regulated protein kinases 5 in sensory neurons contributes to pain hypersensitvity2007

    • Author(s)
      Mizushima, T., et. al.
    • Journal Title

      J.Pharmacol.Exp.Ther 321

      Pages: 28-34

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tissue type plasminogen activator induced in rat dorsal horn astrocytes contributes to mechanical hypersensitivity following dorsal root injury2007

    • Author(s)
      Kozai, T., et. al.
    • Journal Title

      Glia 55

      Pages: 595-603

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frequency-dependent ERK phosphorylation in spinal neurons by electric stimulation of the sciatic nerve and the role in electrophysiological activity2007

    • Author(s)
      Fukui, T., et. al.
    • Journal Title

      Mol.Pain 3.18

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain2007

    • Author(s)
      Dai, Y., et. al.
    • Journal Title

      J.Clin.Invest 117

      Pages: 1979-1987

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of extracellular slgnal-regulated protein kinases 5 in primary afferent neurons contributes to heat and cold hyperalgesia after inflammation2007

    • Author(s)
      Katsura, H., et. al.
    • Journal Title

      J.Neurochem 102

      Pages: 1614-1624

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of fibroblast growth factor receptor by axotomy,through downstream p38 in dorsal root ganglion,contributes to neuropathic pain2007

    • Author(s)
      Yamanaka, H., et. al.
    • Journal Title

      Neuroscience 150

      Pages: 202-211

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of fibroblast growth factor receptor by axotomy, through downstream p38 in dorsal root ganglion, contributes to neuropathic pain

    • Author(s)
      Yamanaka, H., Obata, K., Kobayashi, K., Dai, Y., Fukuoka, T., Noguchi, K
    • Journal Title

      Neuroscience

      Pages: 202-21

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] Sensitization of the P2X3 ATP receptor in primary afferent by proteinase-Activated Receptor 22010

    • Author(s)
      Noguchi.K
    • Organizer
      The Decades of Dubner Scientific Symposium
    • Place of Presentation
      Baltimore
    • Year and Date
      2010-03-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脊髄後角における痛覚伝達の分子メカニズム2009

    • Author(s)
      野口光一
    • Organizer
      第19回神経科学の基礎と臨床
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-19
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 痛みの分子メカニズム2009

    • Author(s)
      野口光一
    • Organizer
      第11回Macnab Memorial Lecture
    • Place of Presentation
      福島
    • Year and Date
      2009-12-05
    • Related Report
      2009 Final Research Report
  • [Presentation] 痛みの分子メカニズム2009

    • Author(s)
      野口光一
    • Organizer
      第11回Macnab Memorial Lecture
    • Place of Presentation
      郡山
    • Year and Date
      2009-12-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Transient expression of TNF alpha in the rat spinal cord following peripheral nerve iujury2009

    • Author(s)
      Kobayashi K., et.al.
    • Organizer
      The 39th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Chicago
    • Year and Date
      2009-10-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Interleukin-1β converting enzyme(ICE)upregulation in spinal glial cells contributes to tactile allodynia after nerve injury2009

    • Author(s)
      Miyoshi K., et.al.
    • Organizer
      The 39th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Chicago
    • Year and Date
      2009-10-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Platelet-activating factor biosynthesis in spinal cord contributes to neuropathic pain following peripheral nerve injury2009

    • Author(s)
      Okubo M., et.al.
    • Organizer
      The 39th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Chicago
    • Year and Date
      2009-10-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 炎症性疼痛の分子メカニズム2009

    • Author(s)
      野口光一
    • Organizer
      第1回日本線維筋痛症学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-10-11
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 痛みの分子メカニズム2009

    • Author(s)
      野口光一
    • Organizer
      第85回聖マリアンナ大学難治研センター大学院セミナー
    • Place of Presentation
      東京
    • Year and Date
      2009-06-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 痛み-その発生機序と臨床的制御の意義-「炎症性疼痛の分子メカニズム」2009

    • Author(s)
      野口光一
    • Organizer
      第53回日本リウマチ学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 痛み-その発生機序と臨床的制御の意義-「炎症性疼痛の分子メカニズム」2009

    • Author(s)
      野口光一
    • Organizer
      第53回日本リウマチ学会総会.学術集会(JCR 2009)
    • Place of Presentation
      東京
    • Year and Date
      2009-04-24
    • Related Report
      2009 Final Research Report
  • [Presentation] Platelet-activating factor biosynthesis in spinal cord contributes to neuropathic pain following peripheral nerve injury2009

    • Author(s)
      Okubo M, Yamanaka, H., Kobayashi K, Noguchi K
    • Organizer
      The 39th Annual Meeting of the Society for Neuroscience (Neuroscience 2009)
    • Place of Presentation
      Chicago, U.S.A
    • Related Report
      2009 Final Research Report
  • [Presentation] 痛みの分子メカニズム2009

    • Author(s)
      野口光一
    • Organizer
      第31回日本疼痛学会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] TRP channels and nociception.2008

    • Author(s)
      Noguchi, K.
    • Organizer
      12th World Congress on Pain
    • Place of Presentation
      Glasgow
    • Year and Date
      2008-08-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] MAP kinase regulation of pain : peripheral, central and glial mechanisms.2008

    • Author(s)
      Noguchi, K.
    • Organizer
      12th World Congress on Pain
    • Place of Presentation
      Glasgow
    • Year and Date
      2008-08-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Neuropathic pain mechanisms : TRP family and signal transduction molecules.2008

    • Author(s)
      Noguchi, K.
    • Organizer
      NeuPSlG satellite to the Glasgow 2008 World Congress on Pain
    • Place of Presentation
      London
    • Year and Date
      2008-08-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Contribution of changes in signal transduction molecules in DRG and spinal cord to neuropathic pain.2008

    • Author(s)
      Noguchi, K.
    • Organizer
      The 3rd Asian Pain Symposium
    • Place of Presentation
      Fukuoka
    • Year and Date
      2008-07-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] 痛みのメカニズム-最近のトピックス-.2008

    • Author(s)
      野口光一
    • Organizer
      特別講演)第22回日本歯科麻酔学会リフレッシャーコース
    • Place of Presentation
      東京
    • Year and Date
      2008-07-13
    • Related Report
      2009 Final Research Report
  • [Presentation] 痛み伝達の調節機構-trpファミリー分子とシグナル伝達-(特別講演)2008

    • Author(s)
      野口光一
    • Organizer
      第22回日本ニューロモデュレーション学会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-18
    • Related Report
      2009 Final Research Report
  • [Presentation] Induction of annexin A2 in rat dorsal root ganglia and spinal cord following peripheral nerve injury.2008

    • Author(s)
      Yamanaka, H., Okubo, M., Kobayashi, K., Noguchi, K
    • Organizer
      The 38th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Washington D.C., U.S.A
    • Related Report
      2009 Final Research Report
  • [Presentation] Laminae-specific distribution of Nav mRNAs in the rat spinal cord2008

    • Author(s)
      Fukuoka, T., Kobayashi, K., Yamanaka, H.., Obata, K., Dai, Y., Noguchi, K
    • Organizer
      The 38th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Washington D.C., U.S.A
    • Related Report
      2009 Final Research Report
  • [Presentation] Upregulation of leukotriene synthesis in glial cells contributes to neuropathic pain following peripheral nerve injury2008

    • Author(s)
      Okubo, M., Yamanaka, H., Kobayashi, K., Noguchi, K
    • Organizer
      The 38th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Washington D.C., U.S.A
    • Related Report
      2009 Final Research Report
  • [Presentation] MAP kinase regulation of pain: peripheral, central and glial mechanisms2008

    • Author(s)
      Noguchi, K
    • Organizer
      (Workshops) 12th World Congress on Pain
    • Place of Presentation
      Glasgow, U.K
    • Related Report
      2009 Final Research Report
  • [Presentation] TRP channels and nociception2008

    • Author(s)
      Noguchi, K
    • Organizer
      (Workshops) 12th World Congress on Pain
    • Place of Presentation
      Glasgow, U.K
    • Related Report
      2009 Final Research Report
  • [Presentation] Neuropathic pain mechanisms: TRP family and signal transduction molecules2008

    • Author(s)
      Noguchi, K
    • Organizer
      (Plenary Lecture) NeuPSIG satellite to the Glasgow 2008 World Congress on Pain
    • Place of Presentation
      London, U.K
    • Related Report
      2009 Final Research Report
  • [Presentation] Contribution of changes in signal transduction molecules in DRG and spinal cord to neuropathic pain2008

    • Author(s)
      Noguchi, K
    • Organizer
      (Symposium) The 3rd Asian Pain Symposium
    • Place of Presentation
      Fukuoka
    • Related Report
      2009 Final Research Report
  • [Presentation] 疼痛伝達の分子メカニズムの解明. (指定講演)次世代の神経科学研究2007

    • Author(s)
      野口光一
    • Organizer
      第313回大阪大学神経科学懇話会
    • Place of Presentation
      大阪
    • Year and Date
      2007-12-22
    • Related Report
      2009 Final Research Report
  • [Presentation] 疼痛伝達の分子メカニズムの解明2007

    • Author(s)
      野口 光一
    • Organizer
      第313回大阪大学神経科学懇話会
    • Place of Presentation
      大阪
    • Year and Date
      2007-12-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] TRP channel family and cutaneous sensation2007

    • Author(s)
      野口光一
    • Organizer
      指定講演)第17回国際痒みシンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2007-09-15
    • Related Report
      2009 Final Research Report
  • [Presentation] TRP channel family and cutaneous sensation2007

    • Author(s)
      野口 光一
    • Organizer
      第17回国際痒みシンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2007-09-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] Roles of ERK5 in spinal microglia and primary sensory neurons for neuropathic pain2007

    • Author(s)
      Noguchi, K
    • Organizer
      Symposium) 7th IBRO World Congress of Neuroscience
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2009 Final Research Report
  • [Presentation] Roles of extracellular signal-regulated protein kinase (ERK)5 in spinal microglia and primary sensory neurons for neuropathic pain2007

    • Author(s)
      Noguchi, K
    • Organizer
      (Workshop) Second International Congress on Neuropathic Pain
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2009 Final Research Report
  • [Presentation] 分子と痛み(1):シグナルと痛み-MAPKを中心として2007

    • Author(s)
      野口光一
    • Organizer
      (特別講演)第2回痛み研究者の集い
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] 分子と痛み(1):シグナルと痛み-MAPKを中心として2007

    • Author(s)
      野口 光一
    • Organizer
      第2回痛み研究者の集い
    • Place of Presentation
      京都
    • Related Report
      2007 Annual Research Report
  • [Presentation] Roles of ERK5 in spinal microglia and primary sensory neurons for neuropathic pain2007

    • Author(s)
      Noguchi, K
    • Organizer
      7th IBRO World Congress of Neuroscience
    • Place of Presentation
      Melbourne
    • Related Report
      2007 Annual Research Report
  • [Presentation] Roles of extracellular signal-regulated protein kinase (ERK)5 in spinal microglia and primary sensory neurons for neuropathic pain2007

    • Author(s)
      Noguchi, K
    • Organizer
      Second International Congress on Neuropathic Pain
    • Place of Presentation
      Berlin
    • Related Report
      2007 Annual Research Report
  • [Presentation] ニューロパチックペインモデルのDRG及び脊髄における分子変化2007

    • Author(s)
      野口 光一
    • Organizer
      第30回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Book] 痛みのメカニズム. 運動器の痛み診療ハンドブック2007

    • Author(s)
      小畑浩一, 野口光一
    • Publisher
      南江堂
    • Related Report
      2009 Final Research Report
  • [Book] Encyclopedic Reference of Pain, 1st ed(Regulation of ERK in sensory neurons during inflammation)2007

    • Author(s)
      Obata, K., Dai, Y., Noguchi, K
    • Publisher
      Springer-Verlag
    • Related Report
      2009 Final Research Report
  • [Book] 痛みのメカニズム, 運動器の痛み診療ハンドブック(山下 敏彦編)2007

    • Author(s)
      小畑 浩一
    • Total Pages
      354
    • Publisher
      南江堂
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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