Identification and analysis of two novel chemokines that regulate glucose and lipid metabolism
Project/Area Number |
19591077
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Endocrinology
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Research Institution | Kobe University |
Principal Investigator |
TAKAHASHI Yutaka Kobe University, 大学院医学研究科, 講師 (70301281)
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Co-Investigator(Kenkyū-buntansha) |
CHIHARA Kazuo 神戸大学, 大学院医学研究科, 客員教授 (00107955)
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Project Period (FY) |
2007 – 2008
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Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | ケモカイン / アディポカイン / 代謝 / 脂肪細胞 / β-細胞 / 糖代謝 / 脂質代謝 / 新規ホルモン / CXCL14 |
Research Abstract |
私たちが同定したGI1とAC1の二つの新規ケモカインについての解析を行った。GI1(CXCL14)は肝細胞においてGHによって誘導されるケモカインとして同定したが、血中濃度がインスリンによって調節されており、脂肪細胞においてインスリン依存性のグルコース取り込みを促進することが明らかになった(BBRC 364,1037,2007)。AC1(ケマリン)は新規アディポカインとして同定したが、脂肪細胞においてインスリンシグナルを促進することを見いだし、FEBS letters 582,573,2008に報告した。
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Report
(3 results)
Research Products
(87 results)
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[Journal Article] Identification and analysis of Prop-1 binding sites in human Pit-1 gene Endocrinology2008
Author(s)
Ikeshita N, Kawaguchi M, Shibahara H, Toda k, Yamashita T, Yamamoto D, Sugiyama y, Iguchi G, Takahashi Y, Kaji H, Chihara K, Okimura Y
Pages
0-0
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Peer Reviewed
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[Journal Article] Hepatic failure and enhanced oxidative stress in mitochodrial diabetes Endocr J2008
Author(s)
Takahashi Y, Iida K, Takeno R, Kitazawa R, Kitazawa S, Kitamura H, Fujioka Y, Yamada H, Kanda F, Ohta S, Nishimaki K, Fujimoto M, Kondo T, Iguchi G, Takahashi K, Kaji H, Okimura Y, Chihara K
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Peer Reviewed
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[Journal Article] Low Serum IGF-I/GH Ratio Is Associated with Abnormal Glucose Tolerance in Acromegaly2008
Author(s)
Fukuoka H, Takahashi Y, Iida K, Kudo T, Nishizawa H, Takeno R, Iguchi G, TakahashI K, Okimura Y, KajI H, Chihara K
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Journal Title
Hormone Research 69(3)
Pages: 165-71
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Peer Reviewed
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[Journal Article] GHRP-2, a GHS-R agonist, directly acts on myocytes to attenuate the dexamethasone-induced expressions of muscle specific ubiquitin ligases, Atrogin-1 and MuRF12008
Author(s)
Yamamoto D, Ikeshita N, Tasaki H, Herningtyas EH, Toda K, Iida K, Takahashi Y, Kaji H, Chihara K, Okimura Y
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Journal Title
Life Sci 82
Pages: 460-66
Related Report
Peer Reviewed
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[Journal Article] Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes FEBS letters2008
Author(s)
Takahashi M, Takahashi Y, Takahashi K, Zolotaryov FN, Hong KS, Kitazawa R, Iida K, Okimura Y, Kaji H, Kitazawa S, Kasuga M, Chihara K
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Journal Title
FEBS letters 2008 582 582
Pages: 573-578
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Peer Reviewed
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[Journal Article] Involvement of mmPOU(Brn-5), a class of IV POU protein, in the gene expression of Pit-1 as well as PRL2008
Author(s)
Toda K, Yamamoto D, Fumoto M, Ikeshita N, Herningtyas EH, Iida K, Takahashi Y, Kaji H, Chihara K, Okimura Y
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[Journal Article] Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency2007
Author(s)
Takahashi Y, Iida K, Takahashi K, Yoshioka S, Fukuoka H, Takeno R, Imanaka M, Nishizawa H, Takahashi M, Seo Y, Hayashi Y, Kondo T, Okimura Y, Kaji H, Kitazawa R, Kitazawa S, Chihara K
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Journal Title
Gastroenterology 2007 132(3)
Pages: 938-43
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Peer Reviewed
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[Journal Article] McCune-Albright syndrome with acromegaly and fibrous dysplasia associated with the GNAS gene mutation identified by sensitive PNA-clamping method2007
Author(s)
Imanaka M, Iida K, Nishizawa H, Fukuoka H, Takeno R, Takahashi K, Kaji H, Takahashi Y, Okimura Y, Kaji H, Imanishi Y, Chihara K
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Journal Title
Intern Med. 46(18)
Pages: 1577-83
NAID
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[Journal Article]
Author(s)
千原和夫
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Journal Title
「NEW薬理学」改訂第5版(南光堂) 2007
Pages: 204-209
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[Journal Article]
Author(s)
千原和夫
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Journal Title
内分泌代謝 専門医ガイドブック((株)診断と治療社) 2007
Pages: 69-71
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[Journal Article]
Author(s)
千原和夫
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Journal Title
今日の診断基準((株)南江堂) 2007
Pages: 325-328
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[Journal Article]
Author(s)
千原和夫
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Journal Title
今日の診断基準((株)南江堂) 2007
Pages: 329-331
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[Journal Article]
Author(s)
千原和夫
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Journal Title
今日の診断基準((株)南江堂) 2007
Pages: 332-334
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