| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
To investigate the functional roles of cytoplasmic protein tyrosine phosphatase Shp2 in the brain, I have generated adult forebrain specific Shp2 conditional KO (cKO) mice by the use of Cre-LoxP system. The effect of Shp2 ablation on the brain functions is now being examined in the cKO mice by the use of several behavioral tests. In this project, I have also investigated a signaling mechanism of tyrosine phosphorylation of SIRPa, which is a major binding protein of Shp2 in the brain, and found that cold-stress induced tyrosine phosphorylation of SIRPa in the brain.
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