Functional analysis of Disrupted-in-schizophrenia 1 (DISC1)
Project/Area Number |
20700333
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Nagoya University |
Principal Investigator |
TAYA Shinichiro Nagoya University, 神経研究所・診断研究部, 室長 (60362232)
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Project Period (FY) |
2008 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | 精神 / 神経疾患の病態と治療 / 統合失調症 / 脳神経疾患 / 脳・神経 / 神経科学 |
Research Abstract |
Schizophrenia is a disease affecting about 1% of the population in the world. However, mpathogenesis of schizophrenia is unclear, several hypotheses are reported. To understand molecular level of schizophrenic pathogenesis, I focused on DISC1 and its interacting molecules. In this study, I showed that DISC1 and its interacting molecules regulate axon elongation, synapse formation, and neuronal migration. These results suggest that the functional analysis of DISC1 leads to molecular level of schizophrenic pathogenesis.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus.2009
Author(s)
Enomoto A, Asai N, Namba T, Wang Y, Kato T, Tanaka M, Tatsumi H, T a y a S, Tsuboi D, Kuroda K, Kaneko N, Sawamoto K, Miyamoto R, Jijiwa M, Murakumo Y, Sokabe M, Seki T, Kaibuchi K, Takahashi M
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Proteomic analysis reveals novel binding partners of dysbindin, a schizophrenia-related protein.2009
Author(s)
Hikita T, T a y a S, Fujino Y, Taneichi-Kuroda S, Ohta K, Tsuboi D, Shinoda T, Kuroda K, Funahashi Y, Uraguchi-Asaki J, Hashimoto R, Kaibuchi K
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Journal Title
Journal of Neurochemistry 110
Pages: 1567-1574
Related Report
Peer Reviewed
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[Journal Article] Association analysis between schizophrenia and the AP-3 complex genes.2009
Author(s)
Hashimoto R, Ohi K, Okada T, Yasuda Y, Yamamori H, Hori H, Hikita T, T a y a S, Saitoh O, Kosuga A, Tatsumi M, Kamijima K, Kaibuchi K, Takeda M, Kunugi H
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Journal Title
Neuroscience Research 65
Pages: 113-115
Related Report
Peer Reviewed
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[Journal Article] Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27.2009
Author(s)
Arimura N, Kimura T, Nakamuta S, T a y a S, Funahashi Y, Hattori A, Shimada A, Menager C, Kawabata S, Fujii K, Iwamatsu A, Segal RA, Fukuda M, Kaibuchi K
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Journal Title
Developmental Cell 16
Pages: 675-686
Related Report
Peer Reviewed
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[Journal Article] Roles of disrupted-in-schizophrenia 1-interacting protein girdin inpostnatal development of the dentate gyrus2009
Author(s)
Enomoto A, Asai N, Namba T, Wang Y, Kato T, Tanaka M, Tatsumi H, Taya S, Tsuboi D, Kuroda K, Kaneko N, Sawamoto K, Miyamoto R, Jijiwa M, Murakumo Y, Sokabe M, Seki T, Kaibuchi K, Takahashi M
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Proteomic analysis reveals novel binding partners of dysbindin, a schizophrenia-related protein2009
Author(s)
Hikita T, Taya S, Fujino Y, Taneichi-Kuroda S, Ohta K, Tsuboi D, Shinoda T, Kuroda K, Funahashi Y, Uraguchi-Asaki J, Hashimoto R, Kaibuchi K
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Journal Title
Journal of Neurochemistry 110
Pages: 1567-1574
Related Report
Peer Reviewed
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[Journal Article] Association analysis between schizophrenia and the AP-3 complex genes2009
Author(s)
Hashimoto R, Ohi K, Okada T, Yasuda Y, Yamamori H, Hori H, Hikita T, Taya S, Saitoh O, Kosuga A, Tatsumi M, Kamijima K, Kaibuchi K, Takeda M, Kunugi H
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Journal Title
Neuroscience Research 65
Pages: 113-115
NAID
Related Report
Peer Reviewed
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[Journal Article] Anterograde transport of TrkB in axons is mediated by direct interaction with Slpl and Rab272009
Author(s)
Arimura N, Kimura T, Nakamuta S, Taya S, Funahashi Y, Hattori A, Shimada A, Menager C, Kawabata S, Fujii K, Iwamatsu A, Segal RA, Fukuda M, Kaibuchi K
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Journal Title
Developmental Cell 16
Pages: 678-686
Related Report
Peer Reviewed
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[Journal Article] Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia2008
Author(s)
Ikeda M, Hikita T, Taya S, Uraguchi-Asaki J, Toyo-oka K, Wynshaw-Boris A, Ujike H, Inada T, Takao K, Miyakawa T, Ozaki N, Kaibuchi K, Iwata N
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Journal Title
Human Molecular Genetics 17
Pages: 3212-3222
Related Report
Peer Reviewed
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