Cellular and molecular basis of hippocampal presynaptic calcium store
| Project/Area Number |
21300146
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurophysiology and muscle physiology
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
KAMIYA Haruyuki 北海道大学, 大学院・医学研究科, 教授 (10194979)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2009: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
|
|---|
| Keywords | シナプス伝達 / カルシウムイオン / 海馬 / 神経伝達物質放出 |
|---|
| Research Abstract |
Subcellular localization of calcium releasing sites from presynaptic calcium store in hippocampal mossy fiber synapse was examined. Using high speed confocal microscope system, calcium imaging within mossy fiber terminals and axons was performed. Calcium indicator was efficiently introduced to single mossy fiber terminals and axons by electroporation through microelectrode placed on visually identified mossy fiber terminals.
|
Report
(4 results)
Research Products
(18 results)
-
-
-
-
[Journal Article] receptor GluN2B (GluR epsilon 2/NR2B)subunit is crucial for channel function, postsynaptic macromolecular organization, and actin cytoskeleton at hippocampal CA3 synapses2009
Author(s)
Akashi K., Kakizaki T., Kamiya H., Fukaya M., Yamasaki M., Abe M. NatsumeR., Watanabe M., Sakimura K. NMDA
-
Journal Title
Journal of Neuroscience, 29(35)
Volume: 29
Issue: 35
Pages: 10869-10882
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
