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The function ofsemaphorin in the formation of neural network

Research Project

Project/Area Number 21590196
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General anatomy (including Histology/Embryology)
Research InstitutionSapporo Medical University

Principal Investigator

TANIGUCHI Masahiko  札幌医科大学, 医学部, 准教授 (70260346)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords神経発生 / 軸索ガイダンス / 脳神経 / ノックアウトマウス / セマフォリン / 中枢神経系
Research Abstract

During embryogenesis, axons reach their specific targets correctly to form the complex neural network found in the mature functional nervous system. Several groups of axon guidance molecules such as semaphorins, ephrins, netrins, and Slits have been reported to repel or attract growing axons that express their cognate receptors. Herein, I report the cloning and characterization of novel semaphorin genes. These semaphorin genes might repel axons of the specific types during development.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (14 results)

All 2012 2011 2010 2009

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (2 results)

  • [Journal Article] Osteoprotection by semaphorin 3A2012

    • Author(s)
      Mikihito Hayashi, Tomoki Nakashima, Masahiko Taniguchi, Tatsuhiko Kodama, Atsushi Kumanogoh and Hiroshi Takayanagi
    • Journal Title

      Nature

      Volume: 485 Issue: 7396 Pages: 69-74

    • DOI

      10.1038/nature11000

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Syntaxin 1B Suppresses Macropinocytosis and Semaphorin 3A-Induced Growth Cone Collapse2011

    • Author(s)
      Kabayama H
    • Journal Title

      J Neurosci

      Volume: 31(20) Issue: 20 Pages: 7357-64

    • DOI

      10.1523/jneurosci.2718-10.2011

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of a novel zebrafish semaphorin2011

    • Author(s)
      Masahiko Taniguchi, Tomoyuki Masuda, Yoshinori Mikami, Masafumi Kimura, Tomoyuki Yoshida, Masayoshi Mishina and Takao Shimizu
    • Journal Title

      Neurosci. Lett.

      Volume: 488 Issue: 2 Pages: 215-220

    • DOI

      10.1016/j.neulet.2010.11.032

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of a novel zebrafish semaphorin2011

    • Author(s)
      Masahiko Taniguchi
    • Journal Title

      Neurosci.Lett.

      Volume: 488 Pages: 215-220

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Syntaxin 1B suppresses macropinocytosis and Semaphorin 3A-induced growth cone collapse2011

    • Author(s)
      Hiroyuki Kabayama
    • Journal Title

      J.Neurosci.

      Volume: 31 Pages: 7357-7364

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of a novel zebrafish semaphorin.2011

    • Author(s)
      Masahiko Taniguchi
    • Journal Title

      Neurosci.Lett.

      Volume: 488 Pages: 215-220

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II2010

    • Author(s)
      Takamatsu H, Takegahara N, Nakagawa Y, Tomura M, Taniguchi M, Friedel RH, Rayburn H, Tessier-Lavigne M, Yoshida Y, Okuno T, Mizui M, Kang S, Nojima S, Tsujimura T, Nakatsuji Y, Katayama I, Toyofuku T, Kikutani H, Kumanogoh A
    • Journal Title

      Nat Immunol.

      Volume: 11(7) Issue: 7 Pages: 594-600

    • DOI

      10.1038/ni.1885

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Semaphorins guide the entry of dendritic cells into the lymphatics via by activating myosin II.2010

    • Author(s)
      Hyota Takamatsu
    • Journal Title

      Nature Immunol.

      Volume: 11 Pages: 594-600

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased proximal bifurcation of CA1 pyramidal apical dendrites in Sema3A mutant mice2009

    • Author(s)
      Fumio Nakamura, Kozue Ugajin, Naoya Yamashita, Takako Okada, Yutaka Uchida, Masahiko Taniguchi, Toshio Ohshima and Yoshio Goshima
    • Journal Title

      J. Comp. Neurol.

      Volume: 216 Issue: 5 Pages: 360-375

    • DOI

      10.1002/cne.22125

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ca2+induces macropinocytosis via F-actin depolymerization during growth cone collapse2009

    • Author(s)
      Hiroyuki Kabayama, Takeshi Nakamura, Makoto Takeuchi, Hirohide Iwasaki, Masahiko Taniguchi, Naoko Tokushige and Katsuhiko Mikoshiba
    • Journal Title

      Mol. Cell. Neurosci.

      Volume: 40 Issue: 1 Pages: 27-38

    • DOI

      10.1016/j.mcn.2008.08.009

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ca2+ induces macropinocytosis via F-actin depolymerization during growth cone collapse2009

    • Author(s)
      Hiroyuki Kabayama
    • Journal Title

      Mol.Cell.Neurosci. 40

      Pages: 27-38

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased proximal bifurcation of CA1 pyramidal apical dendrites in Sema3A mutant mice2009

    • Author(s)
      Fumio Nakamura
    • Journal Title

      J.Comp.Neurol. 216

      Pages: 360-375

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Ca2+induces macropinocytosis via F-actin depolymerization during growth cone collapse2009

    • Author(s)
      Hiroyuki Kabayama, Takeshi Nakamura, Makoto Takeuchi, Hirohide Iwasaki, Masahiko Taniguchi, Naoko Tokushige and Katsuhiko Mikoshiba
    • Organizer
      The 36^<th> Congress of the International Union of Physiological Sciences
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2009-07-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Ca2+ induces macropinocytosis via F-actin depolymerization during growth cone collapse2009

    • Author(s)
      Hiroyuki Kabayama
    • Organizer
      The 36th Congress of the International Union of Physiological Sciences
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-07-29
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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