| Project/Area Number |
21591252
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAMAKI Hiroya 兵庫医科大学, 医学部, 講師 (70416254)
IKEGAME Kazuhiro 兵庫医科大学, 医学部, 講師 (20372609)
FUJIOKA Tatsuya 兵庫医科大学, 医学部, 助教 (70403045)
YOSHIHARA Satoshi 兵庫医科大学, 医学部, 助教 (90461037)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 造血幹細胞移植 / HLA不適合移植 / 移植片対宿主病 |
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| Research Abstract |
A prospective, multiinstitutional study for HLA-haploidentical reduced-intensity stem cell transplantation was performed, and all recipients achieved donor type engraftment in the phase I study. To treat steroid-resistant graft-versus-host disease(GVHD), we developed a novel therapy, "graft-versus-GVHD", in which patients with severe GVHD underwent re-transplantation using a graft from second donor. Furthermore, we established a murine model of MHC-haploidentical transplantation, in which recipients did not develop severe GVHD when receiving lower intensity of conditioning treatment. We found that host regulatory T cells were involved in the regulation of GVHD.
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